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Yes, interesting point, I dont have an axe to grind either way over adjuvants myself but notice it is becoming a hot topic again considering the recent pre-proof by Sepúlveda et al which was published here, discussing HPV and ME. Just when you thought ME research couldn't get any more...

If I understand correctly, according to the description of methods, this data has no controls to assess diagnostic biases. I think ME is underdiagnosed and diagnosis is suppressed by economic, political and professional pressures. From personal experience, getting my own diagnosis was like...

I came across an example today of how limited computer modelling of sequence affinity is, therefore how incomplete a foundation it is for predicting mimic epitopes. The discussion of SARS in relation to other viruses in "virology blog" founded by Vincent Racaniello and featuring David Tuller's...

IMHO We need multiple labs trying to identify the blood factor which is why I backed the Prusty fundraiser and hope the OMF will do their own nanoneedle investigations. What we dont need is people assuming what it is going to be.

This is great and deserves as much exposure as it can get. This study from Professor Leonard Jason et al is invaluable because through common sense epidemiology it provides an accurate narrative to help counter the confusion of preceding decades. The hope being that if decision makers have a...

TWiV (This Week in Virology), the same blog David Tuller writes for about ME, run by Vincent Racaniello, has been very informative about this corona virus. I have been working my way through podcast #586. Recommends washing hands over gels and points out that surfaces may retain other corona...

Can'o'worms. This paper is predicated on speculative computation based guesswork about the possibility that HPV vaccine proteins could mimic human intracellular proteins and trigger autoimmune disease including ME via an hypothetical mechanism involving Treg suppression of autoimmunity as...

I am a bit slow on the uptake sometimes but I have just realised this paper has a reference to the 2015 systematic review of cytokine responses authored by PD White et al (ref 18), as well as the 2017 paper by Montoya et al (ref 19) as linked below. "Cytokine signature associated with disease...

I just want to clarify my last is about the discussion we are having here and not a validation of the approach of these authors. Its obvious after reading the blog link from @MyalgicE and related papers discussing the differentiation of diagnoses that Fatt is a BPS theorist and does not have an...

My guess would be that hypervigilance could also be a behavioural adaptation to being ill, yes it could be to avoid apnea or hypothermia-like falling into deep and dangerous unconsciousness but it could also be about producing sensory hypervigilance in relation to the outside world i.e. light...

I have slept on it and have further criticisms, which are my personal opinion. The first is the lack of empirical data, since the study relies on self reporting which can be subject to biases of the selves involved. This is no more scientific than a poll. There is no attempt to measure...

I was willing to give them the benefit of the doubt except for the following passage as mentioned above, because they do not consider sensitisation as the primary hypothesis for a mechanism, which any self respecting neurologist would surely immediately consider and instead they made an...

Bearing in mind this needs replication to be worthy of treating as fact, my preliminary comment would be the observed impairment of Th17 and MAIT cells is on the face of it at odds with the TH2 shift model where anti-bacterial responses would be expected to be elevated unless you go with the...

I agree its pretty anecdotal and subjective. I am prepared to believe different people respond differently. For some it seems to be much more helpful than it was for me. So the diet may be right for those people, just not me, so I do what is right for me and Dr Myhill encourages and respects my...

I am one of Dr Myhill's patients and I think it makes more sense if you remember she sees a lot of CFS of various causes including organophosphate poisoning, Lymes, unidentified metabolic or hormone disorders etc. In fact I get the impression that viral etiology CFIDS like mine is one of the...

I couldnt agree more.

OK working my way through this, a few things worth mentioning to help other people get into it. B cells are from Bone and T cells are from Thymus. Rituximab targets B cells and cannot treat T cell disease unless it causes B cell disease when it can kill the B cells not the T cells. T cells...

Another thing to be careful of is the old association vs causation error. The association of virus episodes prior to ME onset might be seen as causal, but another way to look at it is that the same unknown etiology might cause both immune failure as an early symptom and ME onset as a later...

They must be aware of the Rituximab results, agree will be interested to see what the full paper is saying. I am just "delighted" they are looking at chronic viral infection as a characteristic symptom of ME...

I am, that fits my CFIDS symptoms to a tee.