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The pressure and mitochondrial migration mechanism sounds like it might be a response to physical growth restriction, maybe a switch to a non mitotic self sustaining mode of living which maximises longevity rather than growth and cell replacement, in a non pathological context. Tumors are a...

What bugs me about the treatment of cancer in the media is the way it is often regarded as if an entity with its own agenda rather than pathology of an organism. If that was the case then it would imply that cancer was due to a reproductory gambit by another organism like a virus. I have not...

This is why imho PWME have a care need. The cognitive impact of abnormal fatigue makes it difficult for one to judge and manage one's own exertion and relapse state, so in theory one needs to be supervised and managed by another party. When I get PEM, I have been having some today I think but I...

Update, whatever bugs or covid variants which are going around are giving me trouble. Seem to have had two variants in succession. Have had headache problems because some of my treatments had to be suspended. I looked at longhaulers forum and realised more symptoms are linked to this...

I would feel embarrassed if I had recommended my MP sign an EDM which was not endorsed by the entire APPG. If it is partisan then it risks not bringing government with it. On the other hand, we have always been a movement of reasonable protest.

good idea, I have done likewise

Apparently there is no visible correlation between LC improvement and time spent fasting according to thefigure in the post by @Utsikt above...

My experience has been that management of ME can significantly influence neurological symptoms. In the ten years I spent without a diagnosis, I tried to push through and suffered all kinds of strange neurological symptoms which harmed my autonomic nervous system as well as my CNS as my brain...

My background in this informs my perspective as I was introduced to programming very young and was writing my own BASIC by about the age of 14 (1978) on a new school Research Machines 380z. I later did some programming for businesses. When the ME hit I was not able or interested to pursue it. I...

In latter years I have had problems with rash around waistbands, even perioral dermatitis etc. Was baffled until I treated it like sweat rash and washed more often than usual and moisturised with skin cream. This is something which was not a problem a decade ago and seems to have developed. My...

If you type in "decode me results" to google, the 'top stories' section gives the SMC top billing, I wonder if that is paid placement? *SMC link warning!!* "expert reaction to unpublished preprint on the DecodeME genome-wide association study of ME/CFS"...

He is quite right of course. Transcribed some salient quotes.

I feel sorry for the hamsters. As an immune induced neurological syndrome though this is a much better model of longcovid and even ME than mouse models based on exhaustion from swimming. To make it more relevant they need to take observations from the hamster model and then make predictions...

I cannot speak for anyone else but cryotherapy would be impossible for me because of my illness diagnosed as ME CFIDS but I can and do use pyrotherapy. Cryotherapy is impossible for me for two reasons, the first is that I have been susceptible to recurring viruses which are triggered by...

https://www.tandfonline.com/doi/full/10.1080/21641846.2025.2530338 Research Article The impact of leading questions on ME/CFS research: bias and stigma in study design Anthony T. T. Campolattara Leonard A. Jason Katherine C. Tuzzolino Courtesy feed from Dr Marc-Alexander Flux

"Association between Epstein‐Barr‐Virus reactivation and development of Long‐COVID fatigue" https://pmc.ncbi.nlm.nih.gov/articles/PMC9538037/ There seems to be a flaw in this logic. You cannot rule out EBV reinfection with this evidence. So the premise that this is proof of reactivation is...

How long is a piece of string? Duration of viral replication signal depends on the virus and the genetics of the immune system of the patient and their nutritional state and physical health. Unknown whether there are masked modes, where an established immune response might hypothetically mop up...

Symptoms are less severe than a cold for me too, just lots of sneezing, mucus and wet tissues / kitchen roll, sometimes alleviating during the day but repeating in the morning for a few days in a row. PS green goop comes at the end of a bad episode for me and is usually indicative of immune...

I sometimes get URT symptoms (particularly in the morning in winter especially if I get physically cold on days beforehand) as part of a cycle of bad and less bad days as part of my ME. This cycle is independent of PEM but PEM can be caused by modest activity all the time and when it coincides...