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Sure it's possible, but I do wander whether there is that much reason as we've seen to specifically argue for that because one already has postulated an underlying disease mechanism which undoubtedly will be complex so can swing in any direction by whatever is going on.

Is it now time for a new type of ME/CFS charity based on stuff like DecodeME? How do we know, when we don't even know whether we can convice some Bob?

I would not be suprised if this is a significant factor. For Long-Covid we saw that the organisation that followed the "most aggressive in words biobabble trend" was by far the most succesful in raising funding. Whilst some charities and researchers are struggling to get pennies together they...

I don't think one even has to go as far as argue that a possibility could exist where exercise worsens the underlying pathology, whatever that may be. There's no evidence that it has any worthwhile benefits and there's simply no point in making people feel horrible if those benefits don't even...

I don't think so. There's a strong indication that he has no idea what he's doing or saying so I wouldn't put much value into his observations whether they are negative or positive. Besides that we have no idea what condition the patients he treats have, maybe they have the spike protein...

Since they mention physical, cognitive, or emotional stressors as confounders for PESE they seem to be aware of some greater picture, despite their focus elsewhere. If someone believes that something is anways just people with maladaptive thoughts then they probably have no reason to think that...

Overall the authors conclusion seems to be: Exercise should be recommended as treatment for ME/CFS as long as it doesn't trigger PEM. But the PACE trial showed that even if you recruit a group of people that don't necessarily have PEM you don't get any worthwhile treatment outcomes. Wasn't it...

Given group differences in comorbidities do the authors clarify what they consider to be comorbid conditions? PEM and PESE are typically used as synonyms. I don't think one can critisise the authors for that. I think the actual question is whether these people experience the type of PEM...

Do we know whether participants had close contact to each other? In times of social media things can sometimes be quite connected, I think @Utsikt mentioned that at least one of the people didn't know any of the other people, but who knows.

Well done @Joan Crawford ! I hope you can now enjoy the warmth of being home with whatever beverage and food you enjoy most.

I can see that others have suggested that a better questionnaire for diagnosis will only have extremely limited use and that seems very reasonable to me. Especially when doctors obviously don’t care about questionnaires for things they don’t even believe in. Only a different kind of education...

A key result also seems to be no difference in POT(s) between patients and controls if the abstract is to be believed.

Thanks. From that I read: Designing tracers that specifically pick up the proteins associated with CTE is difficult (or at least takes a very long time) and using other tracers makes the sort of "patchy but globally spread" proteins hard to distinguish from noise whilst the resolution from PET...

@SNT Gatchaman sorry for this delayed and somewhat vague question: As I understand Chronic traumatic encephalopathy is both a progressive disease neurological disease and also one where post-mortem autopsies deliver conclusive results. It is linked to both p-tau aggregates as well as atrophy of...

I'm also not quite sure how this would be argued as positive evidence for anaesthesia when the exact same argument that is used as negative evidence elsewhere also applies. From what I've seen what people are saying is there have been only very few operations with subsequent remissions and...

Because obviously intra-observer reproducability is not all that matters. Which is what is already well document and has been already been discussed (obviously the number gets bigger when multiple sites are biopsied since this already applies to perfectly healthy controls as shown across studies).

Nobody ever said anybody had to repeat a biopsy. Please read what people write. Intra-observer reproducibility is studied. Results actually seem good but obviously that's not the point.

I think in 5%-10% of those HCs have a positive IEFND. IEFND is well documented to deliver positive and negative results depending on the choice of sample, sample handling and who counts the fibers and on what day of the week. I suspect you need the kind of rigorous methodlogy we hardly ever get...

It isn't because I was never talking about the OMF. You've been talking about other societies, neurologists and rheumatologists. That was the reference (with many of their recommendations not being fulfilled in the ME/CFS study you cited.)

These are type of results why one needs high quality SFN research in ME/CFS not this low quality research. A high quality study would have the skin biopsy analysis blinded to the participant group, since counting intraepidermal fibers involves a large amount of subjective judgment. This is all...