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Now in cinemas "Findings that are never to be replicated- HPA axis 12: Return of the low cortisol."

Is drinking one alcohol free beer and getting a "relaxed feeling" without any drunkeness a genuine placebo-effect? If not, what is it actually? My understanding is that "placebo-effect" is commonly used as a phrase that encompasses all sorts of effects that are not due to a substance or...

Possibly, but I’d also expect that all sorts of people sign up for trials in the hope of getting better regardless of any past experiences. Some trials probably also underreport certain (side) effects and it seems to me it would in many cases be impossible to distinguish something like feeling...

I think similarly. Since we can't attribute improvements to drugs without careful studies, in my head something similar often applies to supplements or medications for largely the same reasons, unless we're talking about already well known side effects. From the placebo-controlled trials we've...

So if I'm understanding correctly: If the people that don't feel pain might be taken as a proxy for the opposite thing possibly happening in Fibromyalgia then you're looking for the equivalent of those non-pain feeling people for ME/CFS, i.e. people that could be taken as proxy for the opposite...

What would be considered as part of sickness response? Does it have to be feeling awful or does feeling just slightly worse but actually still quite fine and good enough to ride the Tour de France count? How does one a "sickness response in ME/CFS" which leaves people disabled compare to others...

The otherside of the medallion is that famous people are regularly seen by quacks that do nonsense. We've seen examples of the "Hollywood celebrities" visiting "ME/CFS specialists" who I'd prefer to stay away from with a 10 feet people. My impression is those that have it best are probably...

From what I understand glympathic dysfunction as cause of Alzheimers is merely a hypothesis for Alzheimers and as pretty much anything else in the field contested. I once read an article on the topic which made it seem like it was people fighting for political prominence with work that had not...

There was no rate of misdiagnosis in the 17 people that took part. They did not have any alternative diagnoses, they were selected on the basis of having ME/CFS (which is defined by the presence of certain symptoms) and ruling out alternative diagnoses. It's certainly possible that someone still...

Looks like @Hutan wrote a study under a pseudonym ;) or perhaps a more fitting title would be: "Can Hutan predict what others will write about Long COVID many years in advance? A Straightfoward Issue."

I can see the possibility that ME/CFS is made up of different pathologies, where one may be similar to CTE, in that there is brain damage that is however not detectable by current imagining techniques (and you'd probably need such a subgroup to be somewhat smaller for autopsies to not have...

This doesn't not seem quite accurate to me. From the data in the supplementary material of the NIH Intramural study: The 217 that were selected had undergone one initial telephone screening interview, I wouldn't consider that very rigorous, but it is of course more rigorous than what we see in...

One of the authors is Willam Robinson whose done a fair bit of work on Herpesviruses in ME/CFS.

But even there the indication for insomnia as far as I can see is only for short term treatment, so not what was seen in this study.

According to the article the control group was matched according to health conditions and medications, however that matching may look. If the differences are as stark as the article suggests I wonder whether looking at different durations and dosages wouldn't have been fruitful if its the...

Indeed but there it isn’t quite sure whether those symptoms are even present in those with viral persistence or whether there’s a possibility that some symptoms align with ME/CFS, but from what I’ve seen people with Ebola persistence often seemed to have no symptoms at all. The post-Ebola bucket...

From what I've seen the people in favour of those theories tend to not argue for HIV or Zika as examples, but rather for things like Ebola, which seems to be able to establish itself in certain immunprivileged sites without leaking out into the blood and without causing progressive worsening...

I thought about this too, it may be the case, but I can also think that it may be that the bias is in exactly the opposite direction: For example people with serious health issues that also have insomnia (say MS, Lupus etc) might be seen be a proper specialist that describes serious drugs for...

Naturally and it's one of the reasons why we should argue for some smart long-term studies tracking patients to understand which phenomena exist.

Of course, but that requires the 2 steps we know very little of and we already know that exercise is not a necessary condition for either.