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MENSA, a Media Enriched with Newly Synthesized Antibodies, to Identify SARS-CoV-2 Persistence and Latent Viral Reactivation in Long-COVID. ABSTRACT Post-acute sequelae of SARS-CoV-2 (SARS2) infection (PASC) is a heterogeneous condition, but the main viral drivers are unknown. Here, we use...

So the paper matched them according to fitness which they defined via aerobic capacity, but Todd thinks this is a bad idea because fitness is not a measure of conditioning. However, at the same time he also thinks that aerobic capacity is equivalent to PEM. I guess I sort of understand his first...

I don't think VO2 level equals fitness (which might in itself be hard to define), otherwise athletes would just be defined by their VO2 levels plus weight. So there's probably some additional variables (for instance recovery time from VO2 max, lactate threshold, muscular pain during exercise in...

Zeta Potential as a Diagnostic Tool to Determine the Angina Risk Abstract Red blood cells (RBCs) moving in circulation are continuously exposed to the reactive oxygen species (ROS) that are circulating within the vascular system of body. The objective of the study is to determine the...

I don't think 81.80% sensitivity sounds bad. In my eyes it would probably be pretty close to what is achievable and considering the results of the intramural study and the problems of finding people with "true ME/CFS" is probably better than one can even expect. Anything much higher probably...

Thanks for clarifying.

I have no idea what any of that is supposed to mean.

I am only getting more confused by Todds words. Is he really saying that PEM is defined as low VO2 and if we don't define PEM like that one is engaging in pseudoscience? Surely he can't be suggesting that... www.x.com/sunsopeningband/status/1809932614159180160

Time for an open letter to question him based on his own statements?

The quotes from the interview sound very sensible and it's the same thing we've heard for years, but looking at the above quotes it seems like an interview talking place in an entirely different reality. If those running RECOVER believe in the above things why are they trialling exercise, light...

It is not a discussion of undiagnosed ME vs "healthy sedentary" people. It’s people that consider themselves healthy and are evaluated as such and are sedentary, but are extremely happy to participate in a clinical trial which induces activity. If I was a “healthy person” that somehow...

That is not what I'm saying either. I'm not familiar with clinical work but I don't think healthy controls are recruited on the basis of not fulfilling the CCC. I'd imagine that is neither how recruitment works nor why HCs participate in this work. They are most likely recruited on the basis of...

Screening phases are talked about in the actual study. For instance I'm not sure I understand your point on false positives and the use of the CCC in the ME group. Application of different criteria for the ME group should have no influence on your controls as false negatives don't end up in...

That doesn't sound very reasonable to me. It's a sedentary control group that has passed different screening phases (see also https://clinicaltrials.gov/study/NCT04026425). I'd be a pretty sure none of those people have ME unless we want to degrade ME to some bengin syndrome. If anything the...

Definitely. But if I recall correctly the turn around for the OMF was somewhere around roughly one publication is produced per 2 million in funding, of course the OMF also do far far more than just publish results but I do hope that this attention the stream is receiving can be used for more...

Cracking the $100 000 is nice. I hope this can somehow be used to continuously inform more people or somehow be used to gain momentum. The attempt at getting Jon Stewart involved looked promising.

I suppose the only "potential" stems from Marshall-Gradisnik's publications which seemingly will never end up leading to anything useful?

Sure that can definitely be the case in a hypothetical scenario. But IIRC within this study all healthy controls looked pretty similar and they also looked pretty similar to pwLC.

I don't think that for now that is a reasonable possibility suggested by any evidence. Billions of people have had multiple Covid infections and remain healthy and perform at the same cognitive and athletic levels etc. Nothing suggests that they are not perfectly healthy. The BPS equivalent...

Would it make sense for some of the B-cell experts to get involved? If only to design the trial in such a way that one can get more meaningful data on a possible role of plasmablasts and plasma cells?