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DecodeME had a question on how well alcohol is tolerated. Did anybody have a look at what the results were and whether there was a difference in the ratio according to sex or whether there were any interesting relationships relating to alcohol tolerance?

But from what I've seen unless you develop something like eye disease, such a phenomenon does not seem to exist in the eyes of endocrinologists. As long as you're thyroid hormone levels are stable you are considered "healthy".

And your arm muscles were even sorer the day following that day (since that's how DOMS usually tends to hit)? I'm guessing one could still argue that the same pathways could somehow be involved but the localization didn't make the phenomenon go haywire or that an additional component is...

Yes, the thing that I thought made the pathway analogy less fruitful was that I thought it would be possible for someone with ME/CFS to develop PEM without DOMS but also to develop DOMS without PEM. I'm less sure whether the second part has been proven or even is true, but it should be possible...

That sounds like a good idea. The focus of the question is actually not whether someone meets every criteria of the CCC (I was planning to write CCC/IOM/SEID, so essentially definitions focused on PEM) but rather that I was trying to differentiate between what nowadays most people consider...

I think that starts the philosophical debate on what ME/CFS entails because definitions such as the Candian Consensus Criteria certainly require PEM for a diagnosis of ME/CFS. Does anbody have a good argument that a definition of ME/CFS not involving PEM is a meaningful clinical category?

Furthermore repeated DOMS tends to only make healthy people fitter, sort of the pinnacle of GET, whilst the opposite appears to be the case for ME/CFS, the PEM threshold doesn't increase just because PEM was previously induced nor does performance increase after repetitive induction of PEM...

It does appear to be that way a bit at least looking at the literature. But maybe similar to how we can see that Long-Covid is a meaningless definition for pathological research there are possibly exercise scientists out there who also have a more meaningful definition. From what I can see that...

Is he trying to tell us that his sister isn't a good listener?

Thanks for the feedback. Yes I think the poll will struggle to capture rather complex situations. I think you have answered the poll exactly in the way I thought would be sensible to ask this question. "Ill" indeed is supposed to only capture acute infections (something pwME that experince...

I think most people on this website usually criticise studies that don't recruit patients according to criteria that are deemed as somewhat meaningful (the CCC or similar). Questions and feedback shouldn't have to be equivalent to a study especially not on a forum where people should like they...

It seems, for whatever reason, no one has expressed much interest in conducting a sleep study in ME/CFS. I wander whether such a study might not carry some valuable insights. Above a poll can be found for people that report sleep problems in ME/CFS following exertion and what happens when those...

I'm less certain whether that is actually a problem with the "ME/CFS label" rather than a very general problem of a lack of follow ups and people just being discarded in the medical system once someone has dealt with them in some way that is deemed as appropriate by the system. There will...

The first problem is that OTS doesn't seem to have a very good definition. Some authors seem to define it as undergoing hard training without adequate rest and the developing a range of unpleasent symptoms that hinder performance, whilst others seem to define it as a plateauing or decrease in...

A risk factor to generate clickbait articles.

For those like me who didn't know this is run by a philantropic organisation founded by Eric (former CEO of Google) and Wendy Schmidt whose foundation holds over $1 billion in philanthropic assets. Apart from fancy buzzwords its however unclear to me what their goals for LC are.

I’d personally like to make clear that I do not defend the use of “allostatic self-efficacy” practices. By contrast I use the ultra homotopic mind-body palace network-respiking-stabilising™ approach. In scientific terms we manage to reorganise ourselves, including a hyper-specialised focus on...

So pacing... Of course that is in contradiction with his last sentence, as pacing is not curative, otherwise people wouldn't have ME/CFS for years...

I prefer "cognitive problems" over "brain fog". What I experience seems similar to what @Haveyoutriedyoga describes, it seems like my brain doesn't have normal power anymore as if from one day to the next my brain aged by 90 years, but more importantly than exchanging one term for another, which...

I don't think that such underestimations are helpful (and I am fairly certain many of them could have obtained a PE major if they had wished to do so). Being smart and a good scholar and being blinded by your own beliefs don't have to always contradict each other or as Feynman said "The first...