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Just for completeness (not that it tells us much) there was also a small study without control group by Iwasaki on this subject Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.

I think hypotheses in medicine have to be able to consistently explain the majority of what is occuring and yield sufficiently good predictions but they don't have to explain the experience of every single person, especially not when there are outliers, different kinds of comorbidities or a...

Thanks! So it seems one can find it if one searches for "ME/CFS" but not when one searches for "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" or "Myalgic Encephalomyelitis".

I suspect if the drug would have efficacy she would quote data from the outcome measures not some speculative correlation?

I searched for the trial on clinicaltrials.gov today and was unable to find it. I think it would be great if the OMF could upload their trial there so that other researchers, doctors as well as patients are aware of it and such that it becomes easier to track as well as understand which...

Hey @Dakota15. I appreciate you digging up all these old news articles but am wandering whether you had any more specific goals in mind? Is it supposed to be a form of documentation and reminder what has been said over the years (I often find that studies I have long since forgotten about and...

From what I've heard from the people that are part of the trial in Erlangen, is that they are seemingly being told that the neutralizing effect of BC007 is high in comparison to placebo. If that was true it would suggest that the drug works as intended, without yielding any efficacy. I'm not...

Seems like an unwise study. The authors should have known: You have to plank and do the rubiks cube at the same time, only that can solve mind-body issues.

I think the crucial point may be that it is precisely such circumstantial evidence that lead people down the viral persistence route in the first place and thus far none of this evidence has stood the test of time (Simoa, Paxlovid etc were all the initial motivators and subsequent studies have...

Seems like all the Polybio projects from phase 1 are still ongoing (for example the numerous "microclot projects") or negative results aren't published or preprints aren't published, does anybody know?

Without any medical education myself, meaning this is all rather worthless blabbering, I wander whether this might not be quite an intrinsic problem in medical research that is often less apparent in some harder sciences (and possibly even more apparent in the softer ones such as sociology) that...

Interesting that they mention no relationship between spike protein concentration to time since last exposure. Could of course be very difficult to quantify as the correct description is likely "time since last known exposure", but I do think it contradicts some other results previously seen.

The problem is however, that the guidelines are not particularly specific, everybody is brewing their own cuppa and that previous research has appeared to be rather arbitrary and not particularly well matched and that the studies often lack data to asses them. In the analysis here the comparison...

I don't think that's a problem here. If the paper compares female POTS patients to female healthy controls (which they appear to be doing) then that is a sufficiently good control already. The male controls can then be viewed as an additional variable to gain further understanding (and it seems...

As horribly grim as those news are, 600 out of 18,718 is not that much, it will depend on where they will be positioned and who the people leaving are. I am more worried by the quote "that half of NIH's research budget should be spent on "preventative, alternative and holistic" medicines."...

I was thinking they maybe wouldn't have done so, they might have just given testimonials and the right of public usage of those without images (and possibly under false names). I think many people wouldn't want to have their picture together with health information open in the public. But I...

To play devils advocate wouldn't it be possible for testimonials to be real but due to data-privacy regulations it not being possible to upload real pictures and names (hence stock pictures and fake names)?

Looks like several clinical trials are planned some of which are: immunadsorption (double blinded), Sonlicromanol (double blinded and placebo-controlled), Minocycline (double blinded and placebo-controlled), SSRI's, proof of concept study for IDO2 adressing medication, rTMS... That's quite...

Whilst the article itself seems to conflate PEM with anything exertion related, it is brillant to once again see that Rob Wüst has understood the difference and that they are not studying PEM, but rather that they are studying the response of muscles to exercise which may or may not have...

Would it be easier when answering a symptom questionnaire to also have a point system for impact of said symptom on daily functioning and how badly one would rate this symptom on a scale of 1 to 5? Might be a bit harder to directly deduce which symptom is "worse" from such a questionnaire, but...