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It reads like they also looked at whether someone reported symptoms for 1-2 months (31%) and then whether they reported symptoms for more than 3 months (10%). If I'm reading that correctly it would be something other studies have mostly not done. At least it suggests that they managed to filter...

I completely agree and my experience with dementia is exactly the same (and dementia also does not seem like a good fit for the reasons you mentioned). I agree that putting such a thought experiment into reality would never be feasible, probably not even be ethical and additionally would be a...

I wouldn't be too sure about that. In the case that dementia is indeed perhaps to complex its possible that someone that is actually knowledgable (rather than being as unknowledgeable as me) might be able to come up with a better example though (possibly some form of brain injury or something...

100% agree. It certainly impacts far more than memory. It's absolutely horrible, live-destroying and impacts every part of daily living for you and those around you and affects everything that once defined you. The question for me is whether there can arise situations in which there is enough...

Yes, for the majority this cannot work. But for the thought experiment it would suffice to find "one patient who can act as their own control" even if the majority cannot. I think that should be possible, at least theoretically (practically is of course a whole different question, I wouldn't...

I see little value in trying to change everybody's mind, that ought to be impossible. As Steven Weinberg put it "All logical arguments can be defeated by the simple refusal to reason logically", but perhaps it matters to be able to change the mind of those that are able to reason logically. I...

The biopsychosocial briefly model claims that ME/CFS is an illness caused by wrong beliefs about ones state with a form of feedback loop feeding into deconditioing which in turn perpetuates these beliefs (similarly the intramural study places a central focus on deconditioning). If a patient was...

I would also think that if Lung damage was an important part of the picture as hypothesised above you'd be more likely to see people which required ventilation and actually had severe lung damage to be more likely to develop ME/CFS. If anything it looks more like the LC-lung damage/PICS...

Something seems to have gone wrong with the text. The spelling errors aren't present in the original PDF.

Don't several pharmaceutical companies also have a hyaluronidase version to increase their market as one is supposedly more convenient? I know Efgartigimod also has a version with hyaluronidase to treat certain autoimmune diseases, with the sole purpose supposedly being convenience. They seem to...

Nice! I thought the one paper on blood-brain-barrier disruption in LC could also be worth a shout with the authors having mentioned interest in ME/CFS.

I fail to see how "ME/CFS Scrutiniser" would be any different from "ME/CFS Skeptic". "ME/CFS Science Scrutiniser" doesn't sound quite as good to me. I quite like @Trish's suggestion of "ME/CFS Research Unwrapped". Similarly I find "ME/CFS Sciencebuster", "ME/CFS Mythbuster" (probably not...

The more reviews I read, the more I am left with the conclusion that either I have not understood the article at all or that the majority of reviewers and presumably a large part of readers, have not understood the essence of the piece at all. I don't know whether the piece itself can make...

I think that may largerly depend on your goals. For all I care you can name yourself XYZ and the analyses of your blogs would still remain as excellent as they have been. However, I do think that it may be very possible that you might have a greater audience, go viral or something the like on...

I think the for most people the association for clinical trials is that you're doing something that has a substantial chance of being harmful to your body and receive a monetary reward in exchange. At least that's how I recall things, with many students making quite a comfortable living by...

I'm not even sure those factors would even have anything to do with ME/CFS. I wouldn't be suprised if taking 2 healthy controls couldn't also give you similar results.

To me this seems like a project very much worth the effort. If there are people that would like to contribute, similar to how @Andy and @Simon M contributed heaps to DecodeME, is there anybody they can reach out to @Chris Ponting?

Seems like those are the only ones left. They have already claimed that Ampligen cures AIDS, cancers etc in the past and have always failed to show any efficacy. The everlasting miracle drug that's still waiting to perform its first miracle.

That at least does implicate that there could be more to this finding. But I suspect the LC diagnosis is still far to noisy by itself. Accounting for severity of acute infection is necessary but there's probably an abundance of other things you have to take into account as well which might not...

I think it is less so about confusing the symptoms and rather ensuring that the result you are obtaining are a result of ME/CFS rather than something else and that will always depend on the study setup. If you're studying cognitive problems in ME/CFS you want to exclude people with Dementia or...