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Nature would also not have published it even if they wanted to respond and I everything they wanted to have been said probably largely already had been said. I don't think you can sensibly blame them for not being engaging in that respect. If anything their response looks like they might have...

It isn't and it shouldn't be and nobody sensibly thinks so, but people tend to like to make conclusions that fit their view of things. But the thing is many authors don't claim any such proof either, because they don't need a proof for their views in the first place, (they just thing the results...

Also note that the reported onset of CFS/ME following Covid is fairly low (and perhaps somewhat more realistic than what has been seen elsewhere but there's no way of knowing whether "CFS/ME" here reflects our understanding of "ME/CFS" for example layed out in the CCC). Out of 36,076 Covid...

I see things differently, as basically what @Sean has already said. "The discrepancy may be due to factors that remain to be elucidated." Just because nothing was found in this study that doesn't mean that the mechanisms have to still be elucidated. The people might have all have MS, Sjörgens...

I'm unsure what you're alluding to here. What is EBV susceptibility supposed to mean? As far as I know pretty much everyone gets infected with glandular fever once and that's normally about it. The Covid problem might be a different one with certain studies picking up risk genes associated with...

Funnily enough one of the people mentioned here w.r.t. to studies showing dramatic benefits across all different things is Ziyad Al-Aly. Given what we've seen in terms of his quality in epidemiolgical research in Long-Covid and his VA cohort, where we know his statements aren't very sensible, I...

No suprising that if you just take a lot of different outcomes some can be claimed to be positive just by chance (as seen in the Erlangen study)...

Yes, but I don't think they are just making general statements about prevalence of ME/CFS in the general population but just some fairly general statements overall. Had it not been for Covid they wouldn't have made any statement at all. And I guess even some of the general prevalence studies for...

Yes, but you'd probably need controls to say anything meaningful and that's what matters. So I don't think the reference to controls is unjustified especially after what has been going on in the Covid literature.

I don't know whether that really makes a difference, I think studies in Germany have been carried out that can roughly be described as "prevalence of ME/CFS following EBV infection" and something similar probably applies to Covid, which is probably the reason why the DGN wrote this in the first...

I think most of alternative science publication and rating models, of which tremendously many exist with different scientists having different preferences for alternative systems, often end up suffering from what some would call "Goodhart's law". I think this goes against the somewhat general...

I can think of scenarios where prevalence estimates following infections have been done where adequate controls would have been useful, something similar probably applies to the studies we've seen looking at different symptoms. I think this version is probably a mild version of what most...

Current statement by the German Neurological Society (translated to english): Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is currently receiving particular political and media attention. It is a complex chronic disease with a wide range of symptoms that is difficult to diagnose...

Hi @nataliee, please don’t feel the need to answer now, but I think some more information on IFL would be good since you’ve seen this as the key point. I’ve tried to get a very rough first understanding at IFL. It seems to me there have been negative results: This small study of people with...

@Andy what would be necessary for the DecodeME data to stay available for say another 10 years? For example say someone wants to re-invite all participants in 5 years and wants to re-run all the genetic data including variables such as "recovered, stayed the same, got worse", what would be...

I will elaborate on why I had this idea that keeping things short in a "follow-up progression survey" might be smart. If one believes that the DecodeME sample is a representative sample of how diagnosed ME/CFS looks like, I have the impression that to be able to get a look at how recovery rates...

One pretty easy and useful project would be to recontact people in say 3 years, 5 years and then 10 years (or similar) to understand more about recovery rates. There might be some bias w.r.t. certain groups being more likely to respond etc but that'd be something that would require close to no work.

I think it's a quite complex, but I don't think anything more complex beyond "these people can't be that sick" is happening. I think in the first instance it's often an argument between doctors: The one doctor says "this" (your GP, company doctor or your specialist), whilst the insurance doctor...

I strongly doubt it. I think linking to the thread on the ME/CFS study would probably be even more meaningful (https://www.s4me.info/threads/restore-me-a-rct-of-oxaloacetate-for-improving-fatigue-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-2024-cash-et-al.40538/), but my...

But that's missing the entire point, it's all already been captured. The insurance physican already has his equivalent of FUNCAP. The stories we are here seeing is patients telling the insurance that they are completely knocked out after walking around the block for weeks, that they crash after...