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Maybe the biggest advantage of ME/CFS research being decades behind is that genetic research is now cheap and robust!

Should it not be fairly easy to look at a comparable to the DecodME cohort (there's very few but I think some smaller ones like some of the cohorts used in the Zhang study seem to meet that description) and do exactly that? I suspect for setting up a new GWAS there's no point to want do a...

I completely see your point, but at the same time I think one can similarly argue that the genes picked up here aren't that much more different in nature to the genes picked out in the FND study which was my main motivation for asking the question in the first place, where that exact argument...

Notably the slight majority of funding did not come from the public sector, but from charities and pharmaceutical companies.

According to the website https://www.ukbiobank.ac.uk/about-us/our-history/ 450 000 participants cost them 200mil in 2019 (400$ per person) and 60 000 participants cost them 30mil in 2022 (500$ per person), so pretty much similar to the cost estimates for SequenceME and of course prices are...

Ok. Now for ME/CFS please. I'm sure someone will analyse whether some of this data is applicable to ME/CFS, but given what we've already seen from the UK bionbank data one probably cannot make any conclusions on the basis of such data.

Or at least lead to the acceptance that one can meaningfully differentiate between sea and land.

I agree, it can be argued that the signals could be stronger if you have say something like a clinical cohort, but I do think it's equally fair to argue that there is also the alternative explanation: It is due to confounding factors (for example comorbidities). I think the larger difference is...

More specifically I was thinking that possibly the next ones to do a suitable GWAS could for example be the german speaking countries (who possibly have some of the higher diagnostic rates, but that may be related to clinicans rather then having to do something with ME/CFS). I was wandering what...

Good question. I think the argument largely always applies, but maybe it isn't always sensible if you can hope that there are some more specific things that make the argument meaningless (if an illness involves a red spot on the forehead then maybe if you do a GWAS on people how have this...

To the gene masters: We now have an idea of the effect sizes of some genes on ME/CFS status based on the UK population. Has anybody looked at the spread of these genes across populations to see whether studies in certain areas make more or less sense? Is that something feasible and does it...

I think it is entirely unlikely that all of the genes that have been picked up are relevant. I think you'd only want to construct a story around a few but nobody has any idea which ones those would be (and it could even be some that are insignificant here).

As others have already mentioned, I don't think lack of replication tells us anything useful. Perhaps lack of replication is even a good thing: We know that according to DecodeME, if anything the effects of these genes on ME/CFS status are small (as to be expected) and we know that something...

Looks like several other outcomes, that have supposedly been part of the trial are not reported on (MRTs, OCT-A etc.).

None of these graphs look impressive and are surely all clinically irrelevant, despite the section bias of only showing those things that even had a positive result. Berlin Cures has to be the happiest pharmaceutical company of all time. Not a dime invested into drug development, patients are...

Safety, tolerability and clinical effects of rovunaptabin, also known as BC007 on fatigue and quality of life in patients with Post-COVID syndrome (reCOVer): a prospective, exploratory, placebo-controlled, double-blind, randomised phase IIa clinical trial (RCT) Background Rovunaptabin...

Yes no specific criteria, just looking at electronic health records. Looks like the codes "Chronic fatigue syndrome (52702003) and/or Postviral fatigue syndrome (51771007)" were then flagged as CFS/ME. It's probably likely that with the emergence of Long-Covid certain physicians don't use those...

The amusing part is that this actually suggests that the authors aren't particularly "mindful" as they can't even get improvements consistent with bias, whilst others that are more "mindful" are able to do that.

A growing number of undercover anti-recovery activists!

Quite possibly, because there's no good validation cohorts in the first place, similar to how DecodeME might struggle to find a valuable validation cohort.