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Yes, but there's something I don't understand about that analogy: If the sickness response is the body telling us to keep quiet because the immune system (or here repair processes) needs extra energy, why doesn't it just tell us to eat more energy gels? (I can understand the genetic and...

I still don't understand. Why do you need to reduce global functioning for local repair processes? Why would they benefit? What are you depriving of the repair processes if you continue life like normal, that is why are the repair and maintenance processes related to keeping the person in...

So the end state of ME/CFS would be: Specific neurons firing too much resulting in symptoms. Now my understanding is that such illnesses exist. My layman understanding is: In epilepsy neurons fire abnormally easily, in channelopathies (but you can also have the opposite problem of hypoexcitable...

So if I'm understanding things correctly DecodeME hints clearly at the brain and likely at neurons, and possibly at synapses but we're not quite sure yet (that is largely coming from the Zhang et al study and some analysis done by @forestglip , but perhaps some caution is warranted). So perhaps...

Would it predict anything? How does lying in bed effect the firing rate of a local region? Perhaps sleeping a lot might reduce overall firing rate, but perhaps the problem is precisely occuring in regions of neurons that also predominantly fire at night? What about an induced coma?

In which part of the body do you postulate that repair and maintenance are not happening? Is it something happening in the muscles (say related to T-cells) or something happening directly in the brain (say synaptic homeostasis)? In the first case, is the repair and maintenance system really not...

My first impression is that I think it may be quite hard to construct a testable theory from this, given the vast complexity of the brain and that "something faulty in neurological signaling related to synapses" still seems quite vague for the beginning. Suppose one had all the hypothetical and...

I'm also not quite sure whether ME/CFS and HIV/AIDS are necessarly on equal footing when it comes to "no conflict of interest". I think we've seen a multitude of examples where the recovery from ME/CFS or similarly Long-Covid and the stories created out of those have created some very strong...

Yes, this part seemed quite strange to me as well. All reviews are equal, but some are more equal than others.

For some funding bodies and grants that is the case.

I think this is the just of what is discussed above: "I propose to call on extitutional scientists to serve as reviewers for scientific publication and grant/funding awards.28 This proposal has precedents: the use of lay scientists as reveiwers has been suggested by extitutional scientists...

I'm not quite sure how Granting Review Power to Extitutional Scientists will work out in reality respecitely how one can effectively manage the potential risks. We on S4ME might argue in one direction but Fiona Symington will happily say the opposite and if I'm wanting a position that fits my...

Maybe I'm not bright enough, but the sentence by the authors you quoted here seems quite sensible to me. If anything I see it as one of the things that lacked understanding in the effort preference conclusions, in that all of the above factors couldn't be accounted for.

Would be interesting to know what the EEG data offers because otherwise this is pretty much the experiment that was done in the intramural study that was used to argue in favor of effort preference (the experiment there addiotionally had TMS data).

That was what me previous post was about. Arguably you could still get there if you allow for enough exploration, but you'd need some way to know whether the millions of things you end up with are sensible and that currently to me seems well outside of the scope in medicine.

I agree that I find the LLM quite the opposite of what one wants to probably be doing very generally: It predicts the most likely sequence of events vs one wants to predict the in some sense least likely sequence of events that can still be contextually made sense of. Arguably that should fit...

I'm pretty sure the comments are about the Prusty study.

Nobody should be suprised if people who don't care about actual evidence make statements not based on any evidence.

I think this has been discussed on various threads and @Jonathan Edwards has put out his views on why there is no evidence of inflammation in ME/CFS, I think the following post captures what has been said: I do actually think it would be good to have one "statement" or quick thread on this, so...

Has data on comorbidities in the ME/CFS patients in the DecodeME patients been released? The protocol says that exclusion criteria are "(ii) any alternative diagnoses including major psychiatric illness (e.g. bipolar disorder or schizophrenia) that can result in chronic fatigue, as explicit in...