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@ryanc97 are you suggesting a single dose of Daratumab in Lupus leads to permanent disease halt without the need for a maintenance therapy? Is there data on that?

Yes, this all understood. This argument doesn't seem sensible to me because you'd have to develop an understanding of why leaving 80% of the problematic factories untouched can result in success which probably requires a deeper understanding of the dynamics. I can understand that there might be...

I don't think this addresses any of my questions or I don't see how because the whole point is that you will still have to develop an antibody theory that is specific to these dynamics (so for example if certain GPCRs go down for months after Rituximab then those won't fit the theory or if I'm...

saline

If someone believes Cyclo is effective and supposed this in shown in the upcoming trial (which is a mssive "if"), then one will have to construct a theory on how it’s possible that the Rituximab trial didn’t show such results. With your belief, that would then probably be related in finding aabs...

There's genetic data for both that could be looked at.

In my head it’s neither of those things, but more related to a “neurological recuperation period” that however has not been pinned down in neuroscience (it's not sufficient to just say "plasticity"). However, every healthy person will be familiar that after having a hard day of cognitive load...

Also note: Certain (including psychiatric) conditions made you ineligible to participate in DecodeME. I don't know how that pertains to depression pre ME/CFS.

The DecodeME questionnaires are available online, here and here (@Andy I also used to be able to find them on the DecodeME website, for example here, but the links seem to have stopped working). I think it is fair to say that they've collected all the information people were asking about. The...

Maybe something for the Twitter folks to share. @Dakota15 maybe a call on social media could be useful, if that is your thing.

Yes, I wanted to emphasise that I find table 2 particularly handy. The amount of ME/CFS studies for which there is no protocol available seems quite damning when every single OI study has an available protocol. I was wandering whether a very short summary of the study results in the table would...

And it only requires a couple of sufficiently expensive session to improve morale in rehab. That is for the practitioner of course.

Thanks for looking into it. I suppose one can dismiss studies using Fukuda criteria in the context of ME/CFS research, but I think it's not quite clear whether one can dismiss them in the context seen here (the authors seem to suggest that these ME/CFS and Long-Covid patients look similar, but...

As you say there's a lot of possibility for p-hacking when you combine different measures together (and there additionally appears to be no correction here) and as you say, the story doesn't sensibly add up because ME/CFS isn't just a story about "acute failure to exert and getting better with...

I remember we had discussed this before. Here is an old post on it to not derail this thread: https://www.s4me.info/threads/traumatic-brain-injury-similarities-with-and-differences-to-me-cfs-including-pem.24965/post-597559.

And that should be surprising? I think most PT's won't knowingly see more than a handful of cases in their time (in the UK there's approx 400 000 ME/CFS cases and 40 000 PTs).

I think it's suprising because one might expect more muscle wastage from inactivity. That's independent of whether one can do something or not with payback.

Many people with post-concussion syndrome suffer from something akin to PEM and I don't think anybody has any idea on what the cause of post-concussion syndrome is.

Hand grip strength was diminished by a median of 4.65 kg after one hour in placebo group, seems to be quite a massive value and doesn't seem to match what is seen elsewhere. If the results are that clear why do people even do CPETs? I wonder whether they checked for maximal exertion during the...

Pyridostigmine/Mestinon is one of the drugs currently being tested in the Lift trial. I think it has also been previously trialled by Systrom.