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To be honest, I don't think it really says that at all because you cannot just read the NK assays like that (you will find enough Rituximab studies with the opposite results anyways especially when things are disease specific). You have to understand the assay in the given context and I'm not...

Fair enough, but was it not you who suggested that RTX works in some cases along the same lines of Daratumumab? Then your counterexample has already been provided. You can't have your cake and eat it too. In any case nobody has yet found a study for Daratumumab where someone did a NK cell...

Yes, but the point is an entirely different one. There's so many NK cells for B-cell depleting medications studies (for the reasons mentioned) that you can find any result you wish to find if you look for it but there is no indication that for example the MM NK cell finding you are comparing the...

Yes, but shouldn't the conclusion of that then be peripheral measurements looking at the count have yielded no results, which is why they had to dig deeper to figure out what's going on, not the opposite?

To show the problems with this approach I just googled "low NK cells+B-cell depletion+success" and was given an abundance of studies, for example: https://pubmed.ncbi.nlm.nih.gov/37081607/. I think we have to be careful comparing things that might have nothing to do with each other simply...

I don't see any reason to think that. Bone marrow NK composition and peripheral blood NK composition are different things (and there's the difference between single-cell transcriptomics and routine clinical flow cytometry NK counts and how the experiments were conducted, things I have no idea...

It needn't have anything to do with illness but could simply be an artefact of study design. In the recently published Charite study, not giving people medication vs giving them medication also seems to have caused large differences in handgrip strength measurements. I wouldn't be suprised if...

As far as I recall the NK measurements in the MM study are not the same as in the Fluge and Mella study and might have nothing to do with each other?

How does "recovering within minutes" fit their same narrative for ME/CFS given that this is clearly not occuring?

We've discussed this idea and possible problems for it on a decodeme follow-up thread: https://www.s4me.info/threads/what-maybe-home-based-useful-new-research-could-be-done-using-the-decodeme-cohort.45191/post-625666...

Interesting that Jos van der Meer is still mentioned to be part of COFFI, whilst at the same time being an advocate for "2-day tilt table testing being an objective measurements of the limitiations ME/CFS causes".

Yes. For example I know that I had my CSF taken but I have no idea whether for example antibodies were examined as part of that. I think quite an important aspect is also that just because a GP sees that a test was negative once it needn't be so in the future, especially if this occured in the...

I see little reason why NK cell count wasn't assessed as part of the Rituximab trial (the measurements were detailed enough for someone to publish a GPCR-aab subset analysis on the basis of the trial data), presumably there is no relationship between responders and NK cell data in the Rituximab...

The only thing real here is likely the lack of a control or perhaps even worse (people participating because there's a chance they'd get the drug and being dissapointed when your in the non-drug group).

The experiments performed by Wüst et al are all published in their paper. There's a slight difference in that Wüst took muscle samples before and after exercise, but some of the results in his study were seemingly not driven by this. If discussing next steps for the study then all of those...

I haven't seen anything about SFN in general (or for diabetes or something else) but only in the context of ME/CFS, LC and FM. I think there's generally 2 tests that are used for SFN: A certain type of microscopy of the eye where a combination of fibre measures is taken and this nerve counting...

I chose to not accept a neuroscience position a couple of years ago, before falling ill, for very similar reasons and decided to rather go somewhere else, essentially because I didn't feel like studying my favorite abstractions of Hodgkin-Huxely without any relevance, but at the same time I find...

The presentation of some results doesn't seem very convincing to me despite being a layman. For example they took skin biopsies of 6 people and then later present the image of the biopsy for one person and claim for 4 other people look sorta the same. Why is it not standard to just present all...

The context of this thread for me is that it seems possible that there's genetic data pointing towards the brain rather than other things and quite possibly that things are different then elsewhere because not only is the illness different and nothing has revealed any anormalities yet, but even...

Whilst I find repeated Radio Gaga in the head quite an amusing analogy I find it to be quite a fitting abstraction for some of the problems pwME/CFS report.