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I think there is a potential difficulty for me in the description of exercise. Are we talking about aerobic exercise like doing specific "exercise" like gym, cycling, running vs a relaxed walk rather than a power walk etc or strenuous activity? eg heavy housework like vacuuming or gardening I...

Thank you, I missed that one. It is good to see they have replicated her work but still unclear the clinical significance which may be made clearer in the preprint you mentioned on a dose response. Could it be a situation of ongoing active inflammatory response in some people with LC? (something...

I recall that an independent laboratory in the north of England, (independent of Pretorius et al), was going to try to replicate her work. I think the lead researcher was a haematologist. That was some months ago and not seen the results on here My concern with this theory is there is no clear...

I have met clients with clinical alcohol intolerance due to a genetic defect in the aldehyde dehydrogenase enzyme. They show facial flushing and rapidly become nauseous, faint, headaches etc. The flushing is very obvious to others and they usually never drink again. I was able to drink alcohol...

That would require some insight into why the ME community are upset by his views, something PG has shown on many occasions not to have. To label us as anti-recovery activists is very inflammatory. I know some people recover. But I know many more that didn't and it is medical profession...

Great article, not much to add. Being a psychiatrist and I did practise CBT for some years, I can only add this from my experience with clients with mental health disorders and the many times I helped people negotiate the sudden change in their life from developing a major mental disorder, some...

Golly, UK psych units sound quite different to NZ ones. Mental health nurses don't barge into people's rooms. Units are run much the same as medical wards but the patients are ambulatory. They do wake clients up to eat meals etc. otherwise they wouldn't get fed. But they can refuse a meal and...

@JellyBabyKid In NZ, DBT skills are being taught at primary school eg.mindfulness, breathing, emotional regulation and distress tolerance skills. It is integrated across the curriculum and has cultural input from tangata whenua (Maori). integrating-mindfulness-into-learning Relationship skills...

@Haveyoutriedyoga yes, part of the neuropsychological examination is distractibility, the ability to maintain attention (sort of like alertness, preparedness) when asked to do a cognitive task. If the clinical psychologist (or psychiatrist who does more simpler tests for cognition), understands...

@SNT Gatchaman Though the structural problem underlying dysfunction may have been very difficult to delineate ex vivo. Yes good point. Nice study. (Translation: Ex vivo - out of the body, post mortem study, that stirred a few brain cells on a rainy afternoon :laugh:)

I think there are central mechanisms involved but there is not enough evidence. I don't think it is a problem with the structure and function of the peripheral nervous system. Neurology has not been able to delineate it. The dorsal ganglion finding is interesting and I do recall this from a few...

So how is the experiment going @SNT Gatchaman? Have you done it on some controls? You hinted at a study. Is it a go-er?

This is awesome! very well written. And reading it, some of these studies are maybe where ME Clinicans have got their information about reduced blood volume in ME? I don't know, but the 20% reduction is often quoted by USA clinicians.

Reduced fitness and muscle function lead to fatigue even in everyday activities. That is incorrect. (well most is incorrect but this is just a small sampling of the rubbish) So did the Swedish ME association provide information and then it was completely reworked by the people doing the...

That sentence in the abstract is too long...A moderation effect..I can't read the paper so what does this mean? a moderate effect? it moderates? OK Google tells me it is a term in statistics and regression analysis, moderation (also known as effect modification) occurs when the relationship...

I haven't read all of the paper but this popped out to me first: self reported valence is one of the metrics gathered in this study. Valence also known as hedonic tone, is a characteristic of emotions that determines their emotional affect (intrinsic appeal or repulsion)...

No, not specifically, we were taught that some people developed post infection fatigue syndromes (ME) but little was known about why they occurred other than it was some sort of immune response. The year I went to med school, 1985, NZ had a mass outbreak of a post infectious syndrome in 1984. It...

I think they are out to save money for the health service. They seem very clear they will try anything without good proven evidence. They also associate non-GI symptoms of this with somatisation (which is a psychiatric term they are now throwing around like confetti!). So add a few symptoms from...

@Paraprosdokian I agree with your approach as a layman with some understanding of medical idemnity. I think being able to successfully claim on your Medical Insurance may be difficult? I know, in NZ, of one psychiatrist who is basically a "psychiatrist for hire" and is also...

Yes, this is the current guidance in NZ. When I went for an eye op under GA a few years ago, I told the anaesthetist at my preop assessment that I had ME and he seemed to know straight away that we are sensitive to some anaesthetic effects and would chose an appropriate general anaesthetic...