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  1. Manganus

    Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics, 2018, Lipkin et al

    First of all, I think all of us see the same: Finally, there is flow! It's no longer only one odd study here, and one odd study there. They actually start to relate to each other, and papers come every now and then instead of just occasionally, as it used to be. This is a pity! :( This is a...
  2. Manganus

    Association of T and NK cell phenotype with the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Rivas et al, 2018

    My brain is nothing to trust, etc., etc., but my impression after reading the paper is that it might be of some value. But it's yet one more of these studies that come up with results that are not immediately possible to translate into clinical practice. It's a good thing they used strict...
  3. Manganus

    Does anyone know how Zopiclone(zimovane/imovane) side effects work?

    I've come to the conclusion that the response to anxiolytics (sleeping pills) seems to be highly individual. And probably much more so among us, than among people of better health. I've myself used Zopiclone, but I don't like the substance much: I may get sleep. But not always, and not for...
  4. Manganus

    What Gorilla Poop Tells Us About Evolution and Human Health

    It hints at a paradigm shift. Certainly, it's not intended as any kind of clinical advice.
  5. Manganus

    Electroconvulsive Therapy

    You may be right. But it doesn't change the fact. It can not be known with the required certainty.
  6. Manganus

    Electroconvulsive Therapy

    No, it can not be known with the degree of certainty that scared laymen wish. On the other hand, we know with great certainty that the alternative is worse - in average.
  7. Manganus

    Electroconvulsive Therapy

    Maybe I wasn't "utterly" against ECT. But humans take their cues from society, and society was against. ;) I see, like you, the difference it makes to (most) treated seriously depressed persons. But it has a cost in the currency memory loss, why it's important to do a careful assessment of the...
  8. Manganus

    Did the David Nutt SAFFE Xyrem drug sleep study ever publish?

    What about doses and prices?
  9. Manganus

    How many hours of sleep a night do you need? - Now with Poll

    Not yet, but I've long wanted to. Instead I use ordinary hashish, decarboxylated and diluted in butter. The mixing with butter has chiefly the purpose to facilitate dosing, but it might possibly facilitate also the uptake in the intestines. It made a huge difference for me when I started, some...
  10. Manganus

    Article and documentary about ME from Finland - Yle Arenan

    Since Finland has been of great interest to me (lots of relatives, lots of visits, etc.), I have of course been interested in dr Polo's case. I've never understood him as specifically scientifically competent. He is a clinician. A typical clinician, I believe.
  11. Manganus

    Brain function characteristics of chronic fatigue syndrome: A task fMRI study, Shan et al, 2018

    I wonder what the reasons are, making Fukuda (1994) still preferred instead of the Canadian Consensus Criteria (2003) and the International Consensus Criteria (2011).
  12. Manganus

    How your mindset determines your health - BBC News website

    There is too much stupidity in this world! :(
  13. Manganus

    Springtime sleepiness - pollen or coincidence?

    I certainly remember something similar from the time I was doing fairly well, healthwise, and studying. For some mystical reason, my stamina and general level of energy shrunk considerably in the spring time - chiefly before the pollen season! Since you write from Norway, and since I've lived...
  14. Manganus

    Leonard Jason wants ME/CFS patients to do a PEM survey

    I agree totally! From the perspective of the questionnaire, we living "overseas" seemed to be more of disturbing exceptions than intended target group. Still, I think it's a laudable initiative. :)
  15. Manganus

    Prof. Mella - Autoimmunity and metabolism in ME/CFS (lecture)

    Wonderful with the transcript! :) :) :) Thanks a lot!
  16. Manganus

    Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome, 2018, Hanson et al

    To state the obvious: ;) Also a null-result is a result. It's of no help in the quest for a biomarker. But in the long run, maybe of help for the general understanding. And lots of subclinical and "insignificant" findings seem to be a typical sign of ME. ;)
  17. Manganus

    A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of ME/CFS (2017) Nilsson et al.

    "Depression" in a study like this is likely classified using the Montgomery-Asberg Depression Scale. But I've not read the paper (due to a currently slow and easily strained brain).
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