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Is 3 points on the 144 point iARDS scale a clinicially meaningful difference? With a 11-fold higher risk of edema and 18.5-fold risk of injection-related reaction, donanemab cannot be said to have a positive benefit-to-risk ratio. If the drug goes on approved by any health authority, this would...

In my view, it is probably best that DecodeME, which is a rigorous scientific study, is not mentioned in an article on a pseudoscientific approach to treating ME/CFS so as to not run the risk of putting them on an equal footing. IIME’s research could have been mentioned given the topic, though...

It is interesting to see that the title was changed from “Eight major errors (…)” to merely “Anomalies (…)”. It is also worth noting that Peter White wrote the paper alone and the other authors only chipped in with comments (which I doubt were more than simple approval): Peer review took more...

Nature podcast with an interview with senior author J.T. Lennon (from 0:46 to 9:20): https://www.nature.com/articles/d41586-023-02232-1

Summary tweet from Dr Veera M. Rajagopal, scientist at Regeneron:

Moger-Reischer, R.Z., Glass, J.I., Wise, K.S. et al. Evolution of a minimal cell. Nature (2023). https://doi.org/10.1038/s41586-023-06288-x Received 15 September 2021 Accepted 06 June 2023 Published 05 July 2023 Possessing only essential genes, a minimal cell can reveal mechanisms and...

Healthcare providers too often forget that recovery is what makes exercise beneficial. Exercise is only one part of the process, namely the stimulus, and there cannot be physiological improvement, be it an increase in cardiovascular fitness or strength or muscle growth, without adequate...

Actimetry and upright time measurement seem essential because if a nutritional intervention involves cooking, this will increase participants’ activity and potentially cause PEM. Meal planning may also induce PEM just because of cognitive exertion. Conversely, if ready-made foods or drinks...

Worth noting is that sugar free electrolyte drinks are useless as sodium requires some glucose to be absorbed in the small intestine (sodium-glucose co-transport mechanism). This is why the WHO formula calls for a small amount of glucose. From the Wikipedia article on oral rehydration therapy:

This study was funded by Institut AllergoSan:

Fair remark. Nonetheless, there is a trap in that conservative skeptics view themselves as healthy skeptics, so Dr English was right to remind those who read this piece of what healthy skepticism should actually be. Hopefully, this made them think twice about their interpretation of skepticism.

by Thomas L. English, M.D. appeared in the Journal of the American Medical Association February 27, 1991 Skepticism permeates our profession. It is ingrained during medical training and reinforced by professional experience. (…) Skepticism is widely perceived as the prudent, conservative way...

Composite reference standards are used to evaluate the accuracy of a new test in the absence of a perfect reference test. A composite reference standard defines a fixed, transparent rule to classify subjects into disease positive and disease negative groups based on existing imperfect tests. The...

It matters a great deal because national health authorities around the world defer to Cochrane. Psychosomaticians who want to incorporate CBT & GET into ME/CFS guidelines could probably find other ways to do so without the Cochrane review, but for now it remains a very handy tool for them...

When researchers like Wyller partake in a series of articles entitled “the ME war” in a tabloid journal (Dagbladet), where the journalists side with them, it seems clear that their goal is to promote their views rather than having a calm and sensible debate about ME.

Having been handed out Dr Ghali’s leaflet on pacing when I consulted him, he is vehemently opposed to pushing through and “pacing up” if it is not feasible. He recommended strict pacing and rest, and that I avoid graded exercise therapy for both ME/CFS and POTS — which he criticized again in an...

Are those the ENFit connectors?

£247,562 of taxpayer money granted to the investigators by the NIHR, yet again. https://fundingawards.nihr.ac.uk/award/NIHR202277

The senior author is Pascal Cathébras, a fierce BPS proponent. It is unsurprising that the Journal of Internal Medicine published this piece as it is a hotspot for BPS internists — they have published dreadful opinion pieces on long Covid, too. Edit: I read the article briefly and the authors...