Search results

It's probably a reference to an ANA test, which can have a pretty high false positive rate: https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antinuclear-Antibodies-ANA

Busse's rapid response in the BMJ had a number of pretty significant basic errors in it (claiming there was no GRADE evidence summary of findings table in NICE, getting the suggested small effect in the Cochrane review wrong, and more) which strongly indicated he had read neither the NICE or...

It's a bit confusing, but there's essentially two different scales going on. There's the different domains for determining the level of the risk of bias of studies (randomization, blinding, attrition, selective outcome reporting), and then that level of the risk of bias of the various studies in...

This is from 2016, not recent

As far as I'm aware there isn't good evidence PoTS can be worsened by deconditioning.

I personally think it's very plausible people with ME are more sensitive to pain than healthy controls, although I wouldn't necessarily trust a study like this to establish that. However why that is, what that means, and whether it has any kind of significance are incredibly open questions.

The context of the article is whether Long Covid is psychosomatic or anxiety or depression. The quote about anxiety and depression is preceded by the article saying that she doesn't believe it's psychosomatic. In that context I don't think there's anything wrong with what she said, in fact, it...

I don't really see how this is a barb. She's just stating what the evidence is

I think their use of the term endophenotype is ridiculous. They ran a study that pretty much found that patients with CFS and FM are more sensitive to pain, and then they're calling it an endophenotype, when that hasn't remotely been established as an endophenotype in any way, shape or form...

"endophenotype"

Strange that he felt the need to do an Op-Ed in the British Journal of General Practice making claims about the etiology and treatment of ME when he didn't even know who probably the most influential researcher in it was at the time. Edit: it's unclear to me whether he was saying he didn't know...

All the studies in this review are retrospective studies, and all of them recruited their patient from specialist epilepsy clinics. They note in the discussion that another review found that the agreement between retrospective and prospective measures of trauma are poor. The leading view of PNES...

Another limitation is that the studies in the review are mostly patients that have been sick in the range of 3-5 years or more, and there are indications people sick for shorter periods have a better prognosis, so this can't be applied to them. Also it seems like they just straight up took the...

I don't think there's anything to be gained from engaging with or paying attention to Garner in any way. He isn't some great authority, he's just someone with quite a narrow field of expertise (applying preset methods used in systematic reviews - the only research he does, and the only research...

I like how he talks about how the brain and body are the most complex in the whole universe, and then somehow manages to turn that into justifying how he knows exactly what's going on.

The idea behind systematic reviews is essentially using systematic methods, such as GRADE and those outlined in the cochrane handbook of systematic reviews to analyse and assess the quality of evidence. The idea is that since the methods are systematic, that eliminates bias, and because they...

Evidence Synthesis is what cochrane does, ie. systematic reviews: https://www.cochrane.org/news/evidence-synthesis-what-it-and-why-do-we-need-it. Garner is co-ordinating editor of the cochrane infectious disease group

It's hard to comment on a specific case, but in other fatiguing conditions sleep usually almost completely ameliorates the fatigue, at least temporarily. Like in MS, the fatigue gradually gets worse over the course of the day, but then sleep ameliorates it: . So someone could find sleep...

Nobody really seems to understand the ramifications of how the Royal Colleges stopped an independent evidence based guideline after already being given a say in the process. That's not how evidence based medicine is supposed to work.

This second piece demonstrates some of the issues with all of this. People are being asked to distrust people that they usually put a significant amount of trust in and respect a lot. If I didn't have ME and I had two people with expertise I trusted tell me the things Tom was told I would...