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Guillemin defended himself, saying: And another scientist said: Although in a blog post that goes into more detail science journalist Leonid Schneider seems very unconvinced that Guillemin had no role in the alleged misconduct...

I rarely enjoy reading what people have to say about the link between ME and mental illness/psychological factors, because it's usually so muddled and vague that it's difficult to actually tell what people are really trying to say.

As Snow Leopard said, there's a lot of different ideas and topics covered in this presentation, as if he wanted to cover as many things as possible. Without the presentation itself it's difficult to tell which ideas he supports, and how and to what extent he supports them. There's definitely...

It should be noted that Kay Hallsworth now has as her pinned tweet a tweet celebrating the new NICE guideline and the derecommendation of Graded Exercise Therapy. In addition to evidence I've mentioned previously in this thread that she does not seem to currently have a pro BPS view of ME/CFS...

The lead author has conducted a fair bit of other research linking other conditions such as diabetes and heart disease to domestic violence. Obviously there's a lot of questions about to what extent these associations are really there, because there's a lot of potential confounding factors. But...

I get the impression in regards to the history/context of the terms "Myalgic Encephalomyelitis" and "Chronic Fatigue Syndrome", it isn't as simple as CFS=Psychiatric and ME=Non-Psychiatric. I think ME may have had an association with hysteria (there was that famous article where two...

It's similar to the idea I believe I've seen that people with somatic symptom disorder are more likely to focus on physical symptoms and deny a psychological cause, and those things are actually seen as a hallmark of it. It's not good scientific thinking at all

I'm very concerned about this non-zero thing. I think it goes beyond the review just being a bad review - it's actively misleading Good work @Caroline Struthers, that was a well written letter

This is something to be kept in mind. Although I appreciate that cochrane is actually making some sort of effort on this review to allow the representation of patients and more unbiased/people with different views on this review. I don't want them to feel like there's no point in trying to do...

I don't recall seeing that thread. I'm not sure to what extent you can judge people by the company they keep (by that I mean I'm genuinely not sure). In things I've seen from him he's talked about how higher standards of evidence should be applied to exercise than what's currently done, and...

When I say I've learnt more about the people as time has gone on, that's from places like twitter, looking people/things up out of curiosity, and trying to learn more about how GRADE/cochrane reviews other things work. Sorry if the way I phrased it was misleading I'm also not really denying...

I wasn't really talking about Julia Newton when I talked about "the best possible people". I meant more "the best possible people under the circumstances", which are not entirely optimal circumstances. I agree that Julia Newton is not an optimal choice, but I assume Cochrane felt pressured to...

As time has gone on and I've learnt a little bit more about some of the people on the author team and the IAG (and thought about some of the other options) I actually think they're better than I expected, and they could well be some of the best possible people that could have been chosen for...

More information about the agreement between cochrane and NICE can be found here: https://www.cochrane.org/news/interview-cochrane-and-nice-collaborate-improve-health-guidelines

By my reading of this correspondence, this makes the previous cochrane review extremely misleading. The reason they chose not to downgrade for imprecision was because they post hoc decided that the question the review was answering wasn't whether exercise therapy had a clinically meaningful...

I think the justification for using the longest followups possible from NICE was that that's what people are actually interested in. I agree with the points made that it's a bit of an unusual thing to do and has the issues which Hutan explained. If, say, they did do the analysis at 52 weeks and...

The committee play a large role in development of the review questions and the protocol though

The systematic evidence review part (ie. the GRADE ratings) of the guideline could be done by people without any involvement in the treatment of the condition, although even then domain knowledge is useful for determining which outcomes are of interest, and other relevant factors like the...

I didn't have particularly high expectations, but the comments from the Royal Colleges are worse than I expected. So many errors, so much misrepresentation, failure to understand basic concepts, baseless assertions. I'm having trouble coming to terms with the fact that some of these people...

It's probably a reference to an ANA test, which can have a pretty high false positive rate: https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antinuclear-Antibodies-ANA