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886 > 188 > 76 > 64 > 39 > 23 ! Yes you can get 2.6% of a patient population to partially participate in a trial - but exactly what does that self selecting 2.6% represent ? The most well ? The most desperate ? The most bored ? 886 people and only 23 thought this was worth pursuing should be...

https://www.wordsense.eu/brain_fog/ "brain fog (uncountable) (informal) A mental condition in which the subject experiences problems in concentrating, thinking clearly, or remembering things. 1886, Mary Jane Holmes, Bessie's Fortune, G. W. Carleton & Co., page 261: Then, as the brain fog...

I think light sensitivity as part of the initial onset of migraine is fairly common but migraine itself is likely pathologically heterogeneous, so in both migraine and ME/CFS the symptom experience may be similar but the route to producing the symptom may vary between sufferers...

Twitter thread by article author:

Article: Science, Blots on a field ?, Charles Piller First para: "In August 2021, Matthew Schrag, a neuroscientist and physician at Vanderbilt University, got a call that would plunge him into a maelstrom of possible scientific misconduct. A colleague wanted to connect him with an attorney...

Seropositivity doesn't = illness, only past exposure to an infective agent. If health is impacted then a global patient population featuring 50+year old rural living males heavily concentrated in Eastern Asia (pop 1.7 bn) would make an interesting contrast to the current picture of Chronic...

Rather than anything substantive to me this paper feels like a Reformation era intra-sectarian counterblast where one group of theologians seeks to lay waste to another group that has suggested a particular scriptural interpretation is/is not heretical. Here's a more substantive counter...

Commiserations - it's always a bit depressing to find there's yet another form of garbage ME/CFS is going to throw at you. I'm not sure typical will show up here - my guess is that these 'sensitivities' get processed through the individual brain in somewhat individual ways. I'd experienced...

The 'nudge' concept has parallels with CBT, has appeared in Government policy “Nudge Unit” including in the area of welfare benefits: Nudging conformity and benefit sanctions: a state experiment in behaviour modification

PNAS Letter: Psychological and Cognitive Sciences, Maier, Bartos, Stanley, Wagenmakers, 2022 First para: Thaler and Sunstein’s “nudge” (1) has spawned a revolution in behavioral science research. Despite its popularity, the “nudge approach” has been criticized for having a “limited evidence...

The Eysenck Personality Questionnaire !!! Why any work by Hans Eysenck should still be considered valid is incomprehensible: Work of renowned UK psychologist Hans Eysenck ruled ‘unsafe’ Personality and fatal diseases: Revisiting a scientific scandal, Pelsoi, 2019 Abstract During the 1980s...

"my research isn’t diagnostic led, so as long as individuals have experience of chronic fatigue they can take part. No diagnosis required."

I think this is the kind of thing that changes people: https://www.theguardian.com/uk/2003/sep/14/animalwelfare.science for Blakemore it stopped being just about the science but the politics of what he understood science to be. Others clearly exploited that with their own claims of 'oppression'...

An in memoriam that doesn't mention CFS, or the minutiae of the SMC: Professor Sir Colin Blakemore FRS Blakemore may have been unhelpful in the cause of finding solutions to ME/CFS but he was an important scientist and science communicator.

I don't think there's anything 'invalid' in what the Griffiths Uni team are doing - it's the way lots of chemical physiology has progressed, teasing apart one element at a time. With TRPICs there's a range of related functions, all of which may operate in different ways...