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Historically, I think that there was a somewhat naive view of body chemistry, that said simply that pro-oxidant activity = bad and antioxidant activity = good, and even more naively that a body can be treated as a single chemical unit and pouring in more of the good stuff must have a beneficial...

Looks a lot like fitting the evidence to the model. Despite quoting large patient numbers: "an estimated 1–5 million people present with CFS in Europe every year" the only references for disease characteristics are two studies in young people which are followed with a defining reference for CFS...

"Many skeletal muscle diseases such as muscular dystrophy, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and sarcopenia share the dysregulation of calcium (Ca2+) as a key mechanism of disease at a cellular level" The only supporting reference for this seems to be Morris & Maes...

Web view: https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science/article/474-exploring-the-genetic-contribution-to-oxidative-stress-in-myalgic-encephalomyelitischronic-fatigue-syndrome/E006619A1543DC159EC835759B2F6BD0#

Given where this is coming from I don't think we should expect any kind of balanced response. Military medicine is primarily about treat and return to duty, or treat and discharge. The UK military does have an excellent record in duty related injury rehab, less so in more general health of...

Do androids dream of judicial review? Challenges to automated decision-making processes in the public sector While the idea of significant decisions being made with no human involvement was once the preserve of science fiction, automated decision-making processes (ADMPs) are increasingly being...

The about turn is just plain weird. The only rational explanation I can think of is that someone at Cochrane ran the issue past their legal advisers and were told to shut it down. I don't think this point should be lost, it is not reasonable behaviour. You were clearly offered a reasonable...

Classifies CFS & ME separately under Neurology, along with neurasthenia (after all it is the 19thC)

Studies ? They quote a single anecdotal number at one clinic from early 2020. Whole thing reads like a clickbait promo for the author's (two are communications specialists) for their institution.

Sorry I misleadingly used the term 'Bastian review' above - as Trish has explained Hilda is slated to lead a PAG which is intended to feed into the subsequent 'new review'. Yes, but IMO if used in argument/complaint needs to be done so with caution and guided by expert knowledge of Charity Law.

Yes, I'm sure that is right. There is though perhaps a different argument about patient safety, where the NICE guideline does have relevance, but identifying where Cochrane's responsibility relative to that might be is contingent on Cochrane's response to Caroline's complaint, and completion of...

We have to start by parsing the respective responsibilities of the Charity (in this case Cochrane), of the Charity Commission and of the Ombudsman – in effect these are a daisy chain. The Ombudsman service (PHSO) will only deal with a formalised complaint about a public body – so in this case...

I've never been directly involved in an Ombudsman complaint, and I'm long out of touch with anything Parliamentary but - my impression is that MPs take the Ombudsman process pretty seriously and don't like being involved in low chance of success cases and/or cases that are other than...

Merged thread How much did the Covid-19 shielding policy cost in Wales? A Retrospective Cost analysis within the EVITE Immunity study Bernadette Sewell, Angela Farr, Ashley Akbari, Andrew Carson-Stevens, Adrian Edwards, Bridie Angela Evans, Ann John, Fatemeh Torabi, Jeremy Dale, Stephen...

It's a question of identifying where the Commission should reasonably take an interest. Process and failures of process are clearly areas where the CC is required by its own terms to have an understanding in both principle and practice, from there it becomes possible to build further arguments...

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In case it helps other readers follow this thread: The Charity Commission (CC) is concerned with process - it issues guidance about how Charities should adopt and institute processes but the CC doesn't specify what every Charity should do - only that there is Charity Law that must be followed...

I could understand a stepped or steep gradient effect between a negative and positive population - we see that in Type2 immunity as mediated by helminth infection* which has a broad poverty/wealth split at GDP per Country. But the gradient in this post COVID study is fairly smooth - there's a...

I was thinking more about a fully formulated complaint to the CC - that is a complaint couched in relevant Charity Law, outlining precisely where the CC is failing (if it is) in its duties in respect of the governance of Cochrane. I think Judicial Review would only be a viable option where it...

I suspect they are similar to most complaints against most Charities. The CC is a weird hybrid organisation - on the one hand it is a Regulator, on the other it is a body charged with supporting Charities and these two sets of duties will often seem to conflict. The CC rationalises this conflict...