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    Protocol Development of a digital biomarker and intervention for subclinical depression: study protocol for a longitudinal waitlist control study, 2023, Teepe

    Development of a digital biomarker and intervention for subclinical depression: study protocol for a longitudinal waitlist control study Gisbert W. Teepe, Yanick X. Lukic, Birgit Kleim, Nicholas C. Jacobson, Fabian Schneider, Prabhakaran Santhanam, Elgar Fleisch & Tobias Kowatsch Abstract...
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    Closed UK: DecodeME updates, was recruitment thread.

    It's a small thing but I feel slightly more validated now that I know someone out there thinks my spit is useful :)
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    United Kingdom News (including UK wide, England, NI and Wales - see separate thread for news from Scotland)

    These newspapers are part of the Reach plc media conglomerate which in addition to three UK national titles - Mirror, Express and Star and the Scottish Daily Record, owns the largest part of UK local media, and although the corporate image is of separate locally published material papers/online...
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    An analogy to explain ME/CFS complexity: Three body problem

    Three body problem https://en.wikipedia.org/wiki/Three-body_problem “The three-body problem is the problem of taking the initial positions and velocities (or momenta) of three point masses and solving for their subsequent motion according to Newton's laws of motion and Newton's law of...
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    The current state of ME/CFS research, and its prospects

    Serious concern about resistance - bad enough with bacteria, but with far fewer antiviral agents, resistance could be catastrophic: Potential Emergence of Antiviral-Resistant Pandemic Viruses via Environmental Drug Exposure of Animal Reservoirs
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    The current state of ME/CFS research, and its prospects

    My answer to both first and second is no. There is a fair amount of workaday biochemistry being done but that seems mostly driven by lab/researcher preferences reflecting either inhouse skill sets or Principal Investigator perspective. Of course there's always the possibility that workaday...
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    Economic Cost of Functional Neurologic Disorders: A Systematic Review, 2023, O'Mahony, Edwards et al

    Excess cost is a commonly used concept in Health Economics - usually a neutral term meaning "extra cost of doing or not doing A compared to doing or not doing B, without additional health/wellbeing gain" e.g Excess cost of care associated with sepsis in cancer patients: Results from a...
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    UK House of Lords/ House of Commons - relevant people and questions

    "Shortly" is code for "it's in the works, therefore I can't/won't give you a date" while "Later date" is code for "we aren't going to commit to timescale". LRM could have asked a supplemental on timescale but would have received a 'put down' response of "As I already replied to the Member....."...
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    One for trading standards? RARP-ID fitness (UK)

    The first ref is from 1998 and the second is mis linked - it leads to a botanical study. What looks like to be intended is Larun et al Exercise therapy for chronic fatigue syndrome . I think that ASA would be a more rewarding line of complaint than Trading Standards - the firm isn't making...
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    The NHS productivity puzzle: Why has hospital activity not increased in line with funding and staffing?, 2023, Freedman & Wolf

    Institute for Government "This report – written jointly report by the Institute for Government and Public First, and funded by the Health Foundation – assesses why NHS hospitals are failing to deliver higher activity despite higher spending on the service and higher levels of staffing over the...
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    UK: Invest in ME Conference 2023

    I realise that an annual conference/colloquium is part of what IIME is set up to do but I do wonder whether it's a model that's past its usefulness. Bringing seven American, one Canadian and four European based researchers to the UK just so they can talk to each other in front of a small...
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    Fit For Work – Three Part Series on BBC Radio 4

    Episode 2 now available: https://www.bbc.co.uk/programmes/m001mlym
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    Stuart Ritchie, science journalist, articles on science fraud and open science

    i News How to see through the AI hype to the actual life-changing scientific advances A new antibiotic discovery shows the promise, but also the limitations, of AI There’s been a lot of AI doom and gloom of late. The newest generation of Large Language Models – OpenAI’s ChatGPT, Google’s...
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    Fit For Work – Three Part Series on BBC Radio 4

    Fit For Work – Three Part Series on BBC Radio 4 by Jolyon Jenkins "For 30 years, governments have tried to get disabled people into work by toughening up benefit rules. Part of the motivation has been to cut the welfare bill, but it’s also been framed as an attempt to stop disabled people...
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    Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19) (outSMART-LC)

    Aerium Therapeutics has only been in existence since 2022 - no track record, although the scientific pedigree seems sound: https://www.aeriumtx.com/ however it's not clear why the Monoclonal Antibodies route would be useful post COVID19 when it's not recommended as a preventative...
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    Psychological flexibility and global health in young adults with and without a self-reported functional somatic syndrome ... 2023, Thomas et al.

    Surely not ! The Psychological Flexibility Model: A Basis for Integration and Progress in Psychological Approaches to Chronic Pain Management "In the current review, we examine models underlying current cognitive behavioral approaches to chronic pain with respect to these criteria. A...
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    Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection, 2023, Thaweethai et al.

    A very unusual study population: This is at variance to other "Long Covid" studies where PASC is associated with higher deprivation numbers.
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    Do labels matter? Implications of ongoing symptomatic chronic illnesses labeled as conventional diagnoses vs. functional somatic syndromes 2023 Smith

    Illness coherence seems to be a term developed out of the ideas of Antonovsky (Health, Stress and Coping) - explanation of which : The Sense of Coherence in the Salutogenic Model of Health and formalised in the Illness Perception Questionaire (IPQ-R) to which Moss-Morris has been a contributor...
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