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I'm having to watch it in 20 minute chunks so it might be answered later on, but is there any indication that this result is going to be published in a scientific journal any time soon? The Davis team has mentioned the plasma swap result a couple of times at conferences now and I'm eager to see...

Yeah, I asked it originally because when I saw MuScle [sic] Disease I thought 'they couldn't possibly mean they're using positive thinking on muscular dystrophy, could they?' and then when I read again I realised that's *exactly* what is planned...

So A vs A+B combined with self-report... no danger of placebo response there then. :speechless: (Edited to remove question... helps if I click through properly...)

Is there anything published or due to be published on the MTHFR finding so far? I read the blog yesterday but it doesn’t give any link that I could see. Would be interesting to get more details. (eg level of stat significance) Anyhow, I didn’t realise they accepted Ancestry as well as 23andMe...

Cheers. I think this would be the sticking point:

Thanks for that! As I was typing it I was thinking 'was it OMEGA?' but was too bone-idle (can't blame my fatigue this time) to check... now fixed.

At the risk of putting the cat amongst the pigeons, is this tentative finding a good case for resurrecting MEGA or an MEGA-like programme? I know MEGA has been controversial (I think I'm one of the few who was tentatively for it) but a large-scale patient repository to allow better-powered GWAS...

This is fascinating. One question I have (and apologies if I’ve misunderstood the article): is the lack of an equivalent result in males/both sexes as a whole because there is no such association in males, or because there is but due to a lack of power it just doesn’t reach the threshold for...

Interesting result and clear the NCNED team are still pursuing their calcium theory. However (as the limitations section notes), this had only six patients and six controls so, even though it found statistically significant differences between patients and controls, it is in dire need of...

I can't see it noted in this paper. The study carried out by Tomas around the same time that also looked at PBMCs used Fukuda criteria.

I wondered the same. If phenylalanine is being diverted to other uses then that might imply difficulty in producing its normal downstream products including dopamine, noradrenaline and adrenaline - which would imply some pretty systemic symptoms like we see in ME/CFS. Xu et al do reference...

This, this and this again :) The original PACE trial and the reanalyses showing its flaws tell us one clear fact: regardless of the underlying pathology of ME/CFS (be it immunological, metabolic, neurological or psychological), Graded Exercise Therapy does not work. Now, that may provide...

I would be cautious with the 98% figure - from what I can understand, it appears that relates to sorting between individual runs, but there were multiple runs per patient, with only 80% of the patients showing this spectral peak. That's not to pour cold water on the study - it really is an...

It's a really interesting study and I'm still trying to get my head around the finer details (I'm not sure my knowledge of spectroscopy from doing A-Level Chemistry a couple of decades ago quite cuts it). It's a pilot study (5 ME/CFS and 5 controls) where 4 of the 5 patients had a distinct...

Just IMHO but I'm not sure going into the comments isn't counterproductive. Seeing people post tens of comments actually plays into the vexatious narrative of the BPS brigade.

I have major brain fuzz today but cannot see from my read-through much of a link with ME/CFS/CFIDS - they just state that the metabolites they've tested are 'implicated in CFIDS' without so much as a citation. Weird.

Yes, seeing 'twenty patients' and 'subgroups' together had my head in my hands. Pretty certain this isn't the first study finding TNF-alpha differences though, will need to have a hunt...

As always, I would caution that NIH data is not particularly up-to-date nor is it presented well - it is entirely possible fewer grants have gone in and/or funding will fall, but that will not be clear until around this time next year when the next update to NIH funding by category table goes...

I have no problem with the term PEM. I think it was Nick Cohen who argued that the danger with online activism today is that it focuses too heavily on changing the language around an issue rather than the (far harder) task of solving the issue itself.

It's an interesting question as to whether ME/CFS is a 'new' illness or not. Certainly it's seen as something that only entered public consciousness in the past few decades. Off the top of my head I can think of three reasons why that might be the case: 1) The hygiene hypothesis: it is true...