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Wow, this looks pretty bad when you see the author is selling this supplement for $333-$1000 per month at the dosages used in this study. I wonder if participants were paying for it and that's why many dropped out. And the trial registration was supposed to be placebo-controlled (and different...

Their "historical placebo" was from a small 1998 fluoxetine and GET trial using the 14-item Chalder Fatigue Scale at 12 weeks, not the 11-item scale they used in this study at 2 and 6 weeks. So perhaps not the best control. Interesting that they didn't show significant improvement on the...

I emailed Prof. Komaroff, but got an auto-reply that he is on vacation.

And Astellas and Systrom are trialing an actual small-molecule drug, while the Axcella thing is more of a supplement (a bunch of amino acids). Pretty different things.

What's fun here is they've flipped the script on the typical anxiety explanation (Long Covid in kids is just anxiety) and are now claiming that not having had Covid means kids have more anxiety about getting Covid and thus report worse functioning. So no matter what the data shows, they'll blame...

This one is weird. They report statistically significantly better physical functioning means in almost all age groups for those infected over controls, plus better emotional, social and school functioning in older age groups for those infected. They want to brush this off as kids who haven't...

We now know that SARS-CoV-1, SARS-CoV-2 and MERS all cause ME-like post-acute conditions in a significant portion of those infected, even those with very mild or asymptomatic infections. Since these are all coronaviruses, specifically betacoronaviruses, has there been any research into other...

Self-selected survey participants, no duration of symptoms specified for Long Covid and a small sample size. I don't think this one adds anything to the conversation.

Agreed. Your data is incredibly varied and points to issues with these studies and the use of the lean test in a clinical setting. It would be interesting to see a study that had participants do a short lean test daily for a couple weeks to see if the kind of variability you have is common in ME...

I also find that being horizontal is pretty important for me in being able to do things, but I'm not convinced it has anything to do with blood pressure or heart rate in particular (just wildly theorizing, it seems to me that these changes might be secondary to whatever is actually the problem)...

It seems like the 30bpm POTS threshold is kind of arbitrary and ME patients often seem to end up just above or below it. About 25bpm on average seems normal for controls.

They seem to be theorizing a fair bit about potential autoimmunity through cross-reactivity with these EBV antibodies. But are the differences between controls and the infectious-onset ME group for these antibodies large enough to make this a potentially significant factor in ME? They sure don't...

If you download the data for the latest ONS Long Covid survey and look at Table 2, you can see the total number of those 17 years old or older with LC for 12+ weeks, then divide by an estimate of the total UK population 17+ in private households, you end up with roughly 2.6% (the overall 3.1%...

Looking at this closer, I think the US question overestimates LC prevalence (because there will be some people who have new symptoms that are not connected to Covid, and are more likely to report symptoms if you prime them while asking with a list of common symptoms). UK ONS survey probably...

Two things jump out at me about this: Long Covid prevalence from this survey is 3 times higher than the UK ONS survey (looking at the comparable number for people 17+ who have LC 12+ weeks after infection). That's strange. Only 40% of Americans know they've had Covid, but that's probably...

The US National Center for Health Statistics has added a question about Long Covid to their Household Pulse Survey. Nearly One in Five American Adults Who Have Had COVID-19 Still Have “Long COVID” New data from the Household Pulse Survey show that more than 40% of adults in the United States...

I cannot figure out what is supposed to be shown in Figure 1. Seems like symptom severity increases for healthy controls according to the top charts, but then the percent change is negative in the bottom charts.

Background: Some patients with acute COVID-19 are left with persistent, debilitating fatigue, cognitive impairment (“brain fog”), orthostatic intolerance (OI) and other symptoms (“Long COVID”). Many of the symptoms are like those of other post-infectious fatigue syndromes and may meet criteria...

Latest video from Ron Davis on the manganese hair study: Sounds like they theorize a lack of manganese in mitochondria and plan to experiment with adding manganese and checking the effect on enzymatic activity. They theorize effects on glucose metabolism and urea elimination, possible...

After thinking about this, I think the study is more likely measuring a significant number of late positives on PCR tests (like a second positive test 6 weeks later from the same infection) rather than only re-infections. And if late positives are associated with post-Covid symptoms, which seems...