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It's not about this post in specific. I have some other questions that are more complex. I don't have the endurance to set up a proper study at the moment and I'm not up to drawing conclusions. I would like to address certain subgroups and cross-reference multiple questions to get a better idea...

I see. It would also require elevated privacy protection and consent because linked data allows profile creation and then, it wouldn't be completely anonymous anymore. It's best this way. However, I could create GDPR-compliant surveys on an external tool and reference them in a post. Would this...

I'm male. For males, it's rather unusual and if it happens, it's more likely to be coliform bacteria or other pathogens traveling from the GI tract. But it could be related to the metabolism as well such as from toxic levels of certain intermediates of the sugar metabolism, or from hemolytic...

@Invisible Woman I added your suggested options. I first had the before option but something went wrong when editing it and now there's the periodical option twice. :facepalm:

I'm asking this because this is what triggered a severe worsening of my symptoms at the time. It coincided with sporadic serum hyperpotassemia but no test or swap had been done on infections.

I had a phase in which I had similar issues, probably triggered by food poisoning. It took years but my GI issues and allergic symptoms are almost completely gone. But I'm still lactose intolerant. I think the undetected lactose intolerance was one of the contributing factors for chronically...

Today, I found this preprint on the efficacy of Ivermectin in COVID-19 prophylaxis and treatment. In the context of COVID-19, Ivermectin looks more promising than any other drug I've read results on. The meta-review is partially based on unpublished data, though; it will take time until all the...

Methylated neurotransmitters and precursors could be monitored via blood+urine. BH-4/BH-2 and other pterins can only be monitored in CSF and would provide better insight into activation and buffer of neurotransmitter metabolism. @Trish @strategist This is exactly what I was hoping for. Thanks!

I was just referring to the general practitioners in my past and their interpretation tables. Certainly, there are references for both blood glucose and Hb1Ac.

PEM has become a mandatory symptom in many CFS guidelines, so I would expect that there is plenty of data of monitored patients during the malaise/fatigue interval because this is when the disease's mechanism of action is amplified and certain biomarkers should stick out and be clearer. Maybe...

One theory I have is that COMT overexpression plays a role in this. COMT overexpression was identified in this study (10.1016/j.jpain.2009.06.003). Via the methionine metabolism, this also has an indirect influence on the immune system via multiple pathways. Firstly, via SAM-e, it reduces HMNT...

Besides the prolonged OGTT, I've never had abnormal blood sugar results either because hypoglycemia only happens rarely and when I feel nauseous, I wouldn't visit a doctor. They were only mildly low (66) and normal reference ranges aren't very adaptive to your age and gender, so nobody would...

At least for the moment. In general, subgroups seem to be difficult to identify if the pathological mechanism and the causality are not well understood. Let's compare it with fever during an infection. Fever is a favorable physiological response during certain infections. Hyperpyrexia is when...

Before my endocrinological checkup, I felt similarly insecure if I should eat when feeling nauseous. Thanks to blood sugar monitoring, I found out how to distinguish hyperinsulinism from hyperinsulinaemic hypoglycemia. This is only my experience and it might be quite different for other people...

@Trish Thanks for the references. @Jonathan Edwards I was not aware of your position. Patients like me certainly appreciate any effort you put into this, and I hope you will keep trying. I agree with you that Rituximab does not show an effect because this is what the trial showed. What I meant...

This is more than speculation imho. Based on this evidence, they built three trial phases of Rituximab (10.1371/journal.pone.0193672). It's open to speculation why the last phase failed, of course, but the antibody test is part of their diagnostic guidelines. I personally have the typical...

I also experience this regularly. Sometimes, I wake up at night and my stomach feels so empty that I feel nauseous. I'm underweight though and could not regain weight yet. In my case, hyperinsulinism has been diagnosed.

I still take L-Carnitine. I take too many things to tell minor differences with this one. There was no significant and notable improvement. I never took Tryptophan due to prior incidents of contamination (WebMD). I still take 5-HTP instead and I could tell a significant difference with this one...

The following is only meant for people with neurological ME as defined by the Charitè CFS/ME center in 10.1016/j.bbi.2015.09.013. They define the disease's mechanism to be mediated by adrenergic- and muscarinergic-binding subtypes of acetylcholine-receptor antibodies. Acetylcholine-receptor...