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Can't it also work vice versa? The transient effects make people believe that the placebo really works so they expect that they need just more of the treatment and that in turn makes them hopeful and let them revise the severity of their symptoms (even if they only experience repeated short term...

(Just leaving some thoughts here before I try to have a bit of a forum break. So apologies if this is somewhat out of context.) What perhaps also needs to be considered is how structural/ systemic bias can impact even objective outcomes. Health care usage, for instance. If doctors have nothing...

It would be interesting to see the full text and know in which way the relationship of objective and subjective measurements exactly differed in each group and between the groups. I have no reason to doubt the correctness of their conclusion: I'd like to know though whether there was a clear...

I'm afraid there are a few more examples of trials that applied objective outcomes, but the trial design is bad for other reasons:

Perhaps one needs to differentiate the risk for bias in in interventions that aim at modifying how people perceive and thus report symptoms? 1) In health anxiety or depression, I think some of the symptoms actually are how patients perceive symptoms. It might still be difficult to...

Or an acronym? IMPRESS bias (Interventions that aim at Modifying how Patients REport SymptomS) (not serious.) I still think it's not just 'one' bias -- it's an entire subdivision of clinicians' distorted perception of certain illnesses and symptoms that implies a complex of biases, including...

Not sure whether this is actually needed. Clinical trials just should apply scales that are both truly validated and relevant for the illness. I think that there exist some good health anxiety and depression scales , but they are validated to measure symptoms of health anxiety and...

This Cochrane database on physical therapies could be helpful? (*) https://www.cochrane.de/sites/cochrane.de/files/public/uploads/gfb/final_cochrane_fur_die_pt_datenbank.xlsx And there's that poster by another group: Physical activity/exercise for health outcomes: an overview of Cochrane...

Indeed. Interesting co-authorship. From a quiick glance, nobody from the Scheibenbogen team involved, but in addition to the three staff members from the private clinic linked above, mostly affiliations with renowned universities, including two authors from the Institute of Psychiatry...

Edit: Three of the authors are affiliated with a private clinic in Germany: https://www.inusmedical.de/start-englisch/ https://www.inusmedical.de/inuspheresis-englisch/ :confused:

It's an updated review, the original is from 1998. So probably just a decadial typo... WHO knows?

But does he really? I don't have access to the review from here and so don't know if the authors explicitly discuss the issue with subjective measures. The only outcome mentioned in the abstract is "improvement in mood" -- that seems to be insufficent to measure symptoms of depression anyway...

Would be interesting to know if there is some sort of chronology in his conclusions from this and similar trials and the subject as well als trial design of following trials? I just began to re-read SW's national elf blog article on the PACE trial. In addition to the ocean liner rhetoric that...

Another point that I don't have the expertise to understand is: Is it really possible to compensate / correct serious shortcomings in trial methodology with some additional statistical work? E.g., again from the example above: I think there are similar examples, also from Crawley and the...

What I most struggle to understand is, when people state that there are several serious risks of bias, shortcomings in the trial methodology, limitations in applicability etc., but that isn't acknowledged in their conclusion. That seems to me to be the case in the assessment of PACE by Students...

Moved from "A general thread on the PACE trial" Cant' assess at the moment if this warrants an own thread and anyway don't feel up to open one, so park some thoughts here: How to deal with the unwillingness of so many people that should know better to acknowledge the issue with subjective...

Trial By Error: #MEAction’s Chronic Illness Survey; Patients’ Research Informs CDC’s Long-COVID Advice https://www.virology.ws/2021/06/15/trial-by-error-meactions-chronic-illness-survey-patients-research-informs-cdcs-long-covid-advice/#more-16069

Trial By Error: #MEAction’s Chronic Illness Survey; Patients’ Research Informs CDC’s Long-COVID Advice https://www.virology.ws/2021/06/15/trial-by-error-meactions-chronic-illness-survey-patients-research-informs-cdcs-long-covid-advice/#more-16069

I'm afraid that this could be an argument that actually doesn't apply. I think mis- / over-interpretation of the evidence base derived from biomedical research made it and continues to make it easy for the proponents of a BPS pathology model to dismiss some of the criticism they receive. It...

I missed that and his name is new to me. Does anyone have a link to provide some info about his support for CBT-GET?