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Sadly, I doubt it will ensure any of those.

Yes, I don't think they were thinking of autonomous feedback loops in brain involving shifts in signalling thresholds. That is what the neuro-developmental and synapse-linked genes raise.

I have not read through the original Fluge and Mella paper but I have heard of them talking about brain loops and synaptic changes much if at all. They seemed to be focusing on immune mechanisms?

I think that is a key argument. If the problem long-term is just in the brain then the brain must be sending out signals to lymphoid tissue to overdo things. While we know there are pathways that could allow that there is a spooky lack of evidence for it really happening in any known clinical...

Loops like this do seem plausible. My caveats would be that if this loop is the normal rules then it should happen to all of us and if it only applies with a genetic nudge we want to know what the nudge is. It looks as if a genetic nudge may only provide a 10-20% lifetime chance of this...

OK, so these are very translational geneticists. They focus on not just biological but clinical role. I don't know what they are planning precisely. We only had the meeting on Wednesday!

It's a bit more subtle than that. They may think someone who says they have CFS may just have been misinformed by a dopy NHS doctor. They think someone who thinks they have ME is more likely to be a disciple of a potty one. which is the catch Fortunately, not everybody is like that, but a lot...

That is probably true for much of the material charities put out. However, it is interesting that there is one major UK group that has wanted to stick to ME, and that gets used in political contexts even if not in patient information. I also think that there are a number of people within the...

Named after Johannes Kristof Blergo of Mannheim. Just like the Greenhouse effect was named after (a corruption of ) Otto von Greinhausen of Schleswig-Holstein. This is actually a fertile area for academic dispute. Surgeons traditionally used a Pfannenstiel incision around the bladder area and...

I can assure you that they do. They tell me about it.

I think one has to assume that people who think they have disease but don't are not like you and I. That of course assumes you are not someone who thinks they have a disease but doesn't. I have worked out that this you are not but I am not sure I can say how. The next step is to try to explain...

I am in favour of Blergo disease, because it means nothing at all.

I doubt it matters but it is important that GPs should have the option of ME/CFS and preferrably just that option. There are no NICE guidelines for ME. Which relates to another point - unless we get agreement on this studies recruiting patients or looking at epidemiology will continue to be...

The problem as I see it is that it means they attract all the meme-spreaders like a magnet attracts iron filings. So we have MERUK, which does some great work funding research, putting out articles on mast cell activation syndrome. We have AfME physicians prescribing mast cell drugs even for...

Things are more complicated than that. There are quite a large number of people who think they have a particular illness and become conversant with the symptom names and may give a textbook account of having that illness but clearly don't. They probably often end up being referred to...

One problem of course is that the 'stress' associated with having a lumbar puncture might be rather different for someone with ME/CFS and for a control. I don't know if there were controls but presumably there were. Were they normal people who for some weird reason volunteered to have a lumbar...

I think people need to realise that the narrative around CFS is very much part of the advocacy ME spiel that has seeped into every corner. Stories that validate the sense of neglect that people with ME/CFS have are seen as plausible but the real story is as much cock-up as conspiracy. After all...

Oh no, he said that the two groups were almost entirely exclusive. People with "ME" were just preoccupied with 'having ME' and had nothing wrong with them. People with CFS did have something wrong with them. But then of course the story changed a bit, once his lymphocyte and HLA studies had...

Yes but if you tell them you have ME they will stifle their grin and say to themselves "well we've got a right one here", just as you would with someone who believes in crystals. Wessely said that people with ME just think they have ME, people with CFS have real problems. He took CFS...

Yes (CA10 is a gene);)