Search results

I think this is a misunderstanding of PEM. Like a lot of clinical concepts PEM is badly defined and described but I don't think it can be reduced to delayed post-exertional worsening of symptoms. It is specifically a worsening of the sort of symptoms found in ME/CFS and is not only unexpectedly...

Would it outdo the Eurovision Song Contest sketch?!! Nul points.

It is good to see that it is there but sadly in the context of a text that indicates a complete misunderstanding of the problem. The rest seems to be an exercise in sycophantic whitewashing. No mention of the fact that NIH helped to cause the Covid-19 epidemic through stupidly misguided policy...

I managed to read all those citations, @Tilly. They are a random mixture of all sorts of arguments linking these things together in various ways but taken together they provide not a shred of evidence for any link between ME/CFS and "MCAS". If anything they are about quite different links with...

Exactly.

But this is exactly the point @Tilly. We know very little. (Although what we do know provides fairly good evidence for there being no relation between 'MCAS' or 'hEDS' and ME/CFS. It is not that nobody has looked. They have, and nothing was found.) And if we know very little it is dangerous...

I know but the paper you cited, as far as I can see was to do with something called B12 that has nothing to do with the vitamin, just has the same name.

Neutrophils are bound to be involved in acute pneumonia but I am not aware of any evidence for inflammatory lesions in 'Long Covid' that could involve NETS. There will be articles in Frontiers and Insights journals implicating NETS because it is the current e-viral meme in medicine. Fifty years...

@Tilly, I don't have time just at the minute to go through all those citations. I will do but just for now. The B12 in the first one seems to be the name of an antibody , not the vitamin. The second concludes: There is no available evidence in the provided studies to support a relationship...

It looks as if peope are having a useful discussion here which I don't have time to engage in just for the minute. But I would question this 'really help some patients' motivation. We don't have good evidence anything helps anybody as far as I can see. Rheumatologists used to believe different...

I don't know where this idea comes from but for postacute sequelae it seems to me totally implausible. It is just the fashion that comes up in almost all seminars on immunologically mediated disease these days. As usual the abstract gives no actual data to support the conclusion the authors...

Yes, that difference does not look pathologically significant to me. I seem to have a post-Covid neuropathy and neuropathy may be an important source of post-Covid symptoms but I don't think this tells us much.

Yes, I think this argument about diagnostic criteria in relation to CBT is counterproductive. As far as we know it doesn't work however broad or narrow the cohort selection criteria. Using CFS to cover 'non-ME/CFS chronic fatigue' is also very unhelpful. Chronic fatigue syndrome was not...

This is just ill-informed pretension. What circulating cells are doing is only indirectly related to inflammation as such and the relation is different for each cause of inflammation. It is a bit like saying you have finally found Jesus Christ - he is a hawthorn tree.

Is there any literature on a link between B12 and/or vitamin D deficiencies and mast cell activation? I am not aware of any link. Hives, B12 and vitamin D deficiencies are all things that should be identified and treated accordingly but that is not what the discussion is about.

Except we do not call them histograms. We call them dot plots or scatter plots and for this type of data they seem to me the obvious thing to use.

There aren't any areas further away from venules. Venules permeate everywhere at a microscopic level.

Capillaries and venules penetrate deep tissues much better than perivascular spaces around arteries, arterioles and veins. Venules normally remove all products of respiration in the vast majority of tissues. I just don't think this is something anyone seriously thinks glymphatics would be...

Neurons may pinocytose as well but this is roughly my assumption, yes. Glia would not be implicated in getting rid of small metabolites like lactate. Those will either diffuse out into venules or be utilised by neurons themselves. I do not see it as credible for a feeble trickly glymphatic...

What is the point in having a rectangle when a dot will do? I cannot see any advantage.