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I am still reading this, but the whole excercise seems not scientifically valid, but I am not educated in these areas, so my question is can they validly make this claim? They are using so few data (2) points and the patients are so far apart on the illness spectrum. I have noticed a typo and...

@Adrian, Thanks for posting that. I tried it out and is was very useful. I liked how it also shows what authors are connected.

Their final statement in the discussion section: We found that anti-SGC IgG levels are elevated in two distinct FM cohorts. The level of these antibodies correlated with a more severe clinical presentation, while being unrelated to FM duration. Moreover, the level of anti-SGC antibodies...

in the discussion they talk about the pooled samples used in the previous paper (as noted by @Jonathan Edwards, @Simon M, @Hutan ,…): In the current study we did not find a difference between FM IgG and HC IgG binding to neurons in culture. We had previously reported elevated IgG binding to...

the image analysis involves using AI. .. Individual cells were identified using Cellpose, a deep-learning neural network (27). Cellpose was run with Python v3.7.9 and the region of interest of each cell were imported into FIJI. Human IgG binding to SGCs and neurons was then assessed in FIJI and...

here they clearly state this is work that continues on from their previous paper. We previously used single patient IgG preparations from eight individuals or pooled IgG preparations from several individuals. Thus, the frequency of FM patients with autoantibodies, and their association with...

For anyone who, like me, wants to learn about satellite glial cells (SGC) here is a good review paper: Emerging importance of satellite glia in nervous system function and dysfunction https://www.nature.com/articles/s41583-020-0333-z

This is going to be slow read for me… Perhaps better educated readers will chime in. I know this Swedish group has been wanting to find a test for Fibromyalgia. From the previously cited Guardian article: The next step will be to identify what factors the symptom-inducing antibodies bind to...

Here is an apparently follow on preprint paper by some of these Swedish researchers plus a group of researchers from McGill University. Fibromyalgia patients with high levels of anti-satellite glia cell IgG antibodies present with more severe symptoms...

perhaps this will help shed some light on the wording these authors use… this is from a previous paper they published in February...

here is an quote from the paper: we selected three major ones including the Fukuda et al. criteria,(15) the Canadian Consensus Criteria,(16) and the Institute of Medicine criteria(17). Those who met more than one case definition (i.e., the Fukuda and either the Canadian and/or Institute of...

I found a copy of the paper at: https://0x0.st/oaF3.pdf

here is one of their conclusions…

@Ravn, thanks for posting those lniks. That is an impressive paper.

here is an update to DeepMind and AlphFold… https://www.nature.com/articles/d41586-022-00997-5?utm_source=Nature+Briefing&utm_campaign=9d0b1cbbb8-briefing-dy-20220413&utm_medium=email&utm_term=0_c9dfd39373-9d0b1cbbb8-45313962

I’m currently pondering whether to do a whole genome sequence test or not and I am hoping to solicit some educated comments. here’s the situation. I live in the USA and my health insurance is Medicare which is the government backed insurance system. My consulting MD is a neurologist at an...

The quest to prevent MS — and understand other post-viral diseases. Nature news. 3/30/22 https://www.nature.com/articles/d41586-022-00808-x?utm_source=Nature+Briefing&utm_campaign=3b524abd63-briefing-dy-20220330&utm_medium=email&utm_term=0_c9dfd39373-3b524abd63-45313962

I thought this was an interesting and hopeful article about the genetic basis for a well-known neurological disease and competing scientists actually working together...

About 10-15 years ago I used to be very familiar with Butler and Mosley theories and the book “explain pain“. They’re famous in the physical therapy (physiotherapy) world in Australia, the UK and the USA. One of the things that I remember was in their book was explaining the push/crash cycle...

Here is a paper discussing the next research step by the same group of researchers. https://academic.oup.com/painmedicine/advance-article/doi/10.1093/pm/pnab338/6443164 Research Recommendations Following the Discovery of Pain Sensitizing IgG Autoantibodies in Fibromyalgia Syndrome: Goebel...