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Neurotypicals tend to prefer harmony over sincerity. The harmony is constructed by putting on a mask to hide one's true feelings and thoughts, making an effort to conform to group consensus, and displaying various behaviours intended to reduce to reduce tension and reassure each other that...

Something similar happened to me. I didn't have difficulty accept the message that I was flawed because I believed in myself. I tried so hard to become a better person, which meant ignoreingmy symptoms as much as possible, but they kept getting worse. I struggled to accept that I was getting...

Avoiding telling the truth while dropping hints is the approach for psychological disorders because people cannot instantly accept that they are the reason for their problems. They have to gradually accept that and see it for themselves. The BPS people have been trying to apply a similar...

I'm not sure how to best set up my desk so that I can study while reducing orthostatic intolerance. I need the PC and a place for books. I need something ergonomical for the hands and eyes. I don't want to lie horizonally while studying.

They see ME/CFS as something like a psychological disorder. If you have a psychological disorder, the only cure is to understand how your own behaviour and thoughts are causing the problems in your life. That's why therapy emphasises taking personality responsibility (instead of blaming...

I believe it's just a manifestation of exertion intolerance, that manifests slightly differently depending on the type of exertion. Mental exertion appears to affect the brain more prominently or differently compared to upright position, muscular and cardiovascular exertion, and this manifests...

Interesting anecdote about an egg improving sleep. I once had amazingly good sleep, after eating a rich bone broth and meat soup (similar to Ramen soup). My other family members also said that they slept unusually well that night. Does anyone have an idea what amino acids or substance in the...

I started studying regularly to exercise my brain and since then I have noticed a shift in my symptoms. I've started to notice all the noise coming from outside and how uncomfortable it is. Dogs barking, distant and near traffic, people talking, music in the distance, machinery humming, wind...

I also believe psychologization of unexplained illness is one of the factors that drives people towards alternative medicine. Treat people like idiots or children, show them that they are not valued, lie and attempt to manipulate them, give them bullshit placebo treatments, prioritize the...

My mother subscribed to the emailing list of one of these people and over time was influenced by them. It started with an interest in healthy nutrition and things that could help her sleep. Especially during the pandemic she bought into all the weird misinformation and blamed Bill Gates, thought...

ChatGPT says The average person has about 100 predicted-loss-of-function variants (pLoF), but in the average healthy person, there are only 0-2 heterozygous pLoF variants in LoF intolerance genes. Homozygous pLoF variants are usually incompatible with life and extremely rare. Most of the pLoF...

COFFI doesn't understand GWAS. They are based on studying common SNPs, so inevitably, they will be present in healthy controls at very similar rates. The goal is not find to the genes with largest impact, but to identify the regions associated with the disease. This permits more precise study...

Over at COFFI, people seem a little rattled and worried about the credibility of their rehab claims. There isn't much substance either in their comment. I suppose the take-home message is that DecodeME did a good job.

I've had several enlarged lymph nodes at least 5 years before the illness onset. Is it possible for the immune problems to begin years earlier, but symptoms to only appear later, when an additional vulnerability is present that is required to develop the illness? At least that seems like it...

Does the increased risk for some forms of lymphoma fit as well?

It would vaguely fit with some aspects. I noticed that concentrating intensely on something can switch on something that feels like an overexcited mental state that does not dissipate easily and has negative effects.

I have a potential loss of function mutation in one allele of the PER1 gene. It works together with the CLOCK gene and some others to create the circadian rythm. This probably doesn't have a serious impact on its own but the genes in this category seems like good candidates for risk factor genes.

I'm interested in this idea. Would this information be memories of events, or more things like information about physiological?

Something like this has been mentioned by @Jonathan Edwards on multiple occasions, and the term memory has come up, and I'm curious what is meant and how it would work. I'm getting the impression that the idea is information related to physiology accumulating over the course of the day in...

Yes, something similar appeared together with a variety of other circulatory symptoms related to small fiber neuropathy and POTS. For example I had difficulty sitting in a normal position because after a short time (minutes) parts of my leg and buttock would fall asleep. As result in some...