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I'm not sure how relevant this is to the discussion now, but something of personal experience came to mind while reading this. I was for years effectively denied medical care and given psychological care instead, I believe due to the ME diagnosis. I was believed by my GP's to have 'CFS' from...

Surely it's not that the mtDNA 'causes' the ME so much as it sets up an environment where ME can be triggered at some point in life if the right other conditions occur, such as the right virus infection or immunisation shot or whatever finally triggered the ME