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If it's even slightly helpful, I downloaded the auto-generated subtitles (via DownSub) and removed the ums, ahhs, errs etc. (It's still a lot of text though).

Research letter responding to this paper SARS-CoV-2 spike protein can bind fibrinogen, but does not alter plasma fibrin formation, clot structure, or lysis (2026)

That control was evaluated for people with psychosis. Ref is The Credibility and Acceptability of Befriending as a Control Therapy in a Randomized Controlled Trial of Cognitive Behaviour Therapy for Acute First Episode Psychosis (2006) —

I thought this was an interesting passage. Signals relating to mitochondria, metabolism, rho GTPases, neutrophils (granzyme, NETs), myosin, neurogranin (synapses again) and HDAC — Lectin and ficolin get a mention —

National Institute of Environmental Research (NIER), 2020. Study for Improving Recognition and Judgement Standard of Health Damage of Humidifier Disinfectants (Ⅲ). NIER-SP2020053, p74-100 (in Korean). Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic...

Cytoskeleton derangement is implicated with organophosphates more generally — The Neuronal Cytoskeleton as a Potential Target in the Developmental Neurotoxicity of Organophosphorothionate Insecticides (2014, Basic & Clinical Pharmacology & Toxicology) The cytoskeleton as a non-cholinergic...

They speculate on bone marrow and effects on stem cells via cytokines.

I can't see that they've specified which or how many patients qualified under any of the three criteria: Fukuda, CCC, ICC. Similarly they don't give the Bell score, instead — (All but milder 3 M and 2 F were in the 4-7 range)

Don't love this part of the discussion — [7] is Physical activity in chronic fatigue syndrome: Assessment and its role in fatigue (1997) which includes the following on deconditioning — This paper continues — Which is all very pacing-up and BACME-like.

[31] is Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations (2024) which is open access. Bell Activity scale for the group was 35.5 (12.0), a...

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@dave30th FYI. Something you might like to reference if/when commenting on The Lancet in future. From David's 10 years in review blog —

Developmental convergence and divergence in human stem cell models of autism Two decades of genetic studies in autism spectrum disorder (ASD) have identified more than 100 genes harbouring rare risk mutations1,2,3,4,5,6,7,8,9,10,11,12,13. Despite this substantial heterogeneity, transcriptomic...

Chris Ponting reaction at Science Media Centre —

Rehabilitation needs of long COVID patients in British Columbia Débora M Petry Moecke; Evan H Kwong; Sonya Cressman; Jennifer Yao; Chiara Singh; Carolyn Taylor; Pat G Camp INTRODUCTION COVID-19 can result in persistent symptoms and functional impairment that significantly impact daily...

Genetics and environment distinctively shape the human immune cell epigenome The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation...

Did a Celebrated Researcher Obscure a Baby’s Poisoning? [Archive] After a newborn died of opioid poisoning, a new branch of pediatrics came into being. But the evidence doesn’t add up. A long read. Summary quotes —