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  1. Hip

    An Alzheimer treatment: lecanemab (Biogen)

    Vincent Racaniello on his virology blog summarizes the evidence for HSV as the cause of Alzheimer's:
  2. Hip

    An Alzheimer treatment: lecanemab (Biogen)

    I had some email conversation with this Alzheimer's researcher, Prof Ruth Itzhaki, about 5 years ago. I contacted her because I knew of her research into the herpes simplex virus (HSV) link to Alzheimer's, and I wanted to let her know about the Pridgen antiviral protocol for fibromyalgia (which...
  3. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Not sure if this question has been answered, but here is a list of 32 cervical medullary syndrome (CMS) symptoms I found from various sources: Headache • Neck pain Bobble head Muscle or joint pain • Weak legs • Weak arms or hands • Numb legs and back • Numb arms/shoulders • Unsteady walking...
  4. Hip

    Signs of Intracranial Hypertension, Hypermobility and Craniocervical Obstructions in patients with ME/CFS (Pre-print 2019/published 2020) Bragée et al

    Of the 53 ME/CFS patients positive for CCI in our survey, 36% experience either transient paralysis (eg, breathing muscles fail) in certain head/neck positions, or a worsening of symptoms in certain head/neck positions. So there is head/neck position sensitivity in some ME/CFS CCI patients...
  5. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Of the 53 ME/CFS patients positive for CCI in our survey, 36% experience either transient paralysis (eg, breathing muscles fail) in certain head/neck positions, or a worsening of symptoms in certain head/neck positions. So there is head/neck position sensitivity in some ME/CFS CCI patients...
  6. Hip

    Signs of Intracranial Hypertension, Hypermobility and Craniocervical Obstructions in patients with ME/CFS (Pre-print 2019/published 2020) Bragée et al

    The range of CXA in the healthy population is 160 to 145, and I believe I saw a paper stating that average CXA in healthy people was 158 (but I cannot find the paper at the moment). So an average of 148 is less than normal. Don't forget that a pathological CXA is just one way that you can have...
  7. Hip

    Signs of Intracranial Hypertension, Hypermobility and Craniocervical Obstructions in patients with ME/CFS (Pre-print 2019/published 2020) Bragée et al

    Yes, that's right, as I understand it, pathological range craniocervical measurements alone are not sufficient for a CCI diagnosis. Rather the diagnosis of CCI is made via a combination of factors, which includes the patient's craniocervical measurements like CXA, Grabb-Oakes and BAI, but also...
  8. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    This post has been copied from this thread. If you want to discuss it please do so here. Yes, that's right, as I understand it, pathological range craniocervical measurements alone are not sufficient for a CCI diagnosis. Rather the diagnosis of CCI is made via a combination of factors...
  9. Hip

    Open Cervicocranial dysfunction, neuroinflammation and infection in ME/CFS compared to healthy subjects, Bragée & Bertilson [MEPRO study]

    I did not know he authored such a paper; if you happen to have link to it handy, I'd be interested to see it.
  10. Hip

    Open Cervicocranial dysfunction, neuroinflammation and infection in ME/CFS compared to healthy subjects, Bragée & Bertilson [MEPRO study]

    I guess it is possible lying flat might improve symptoms in some patients (and some ME/CFS patients with CCI have reported feeling better lying down — though this could also be due to POTS). But I am not sure how common it is for CCI patients to have craniocervical measurements which only...
  11. Hip

    Signs of Intracranial Hypertension, Hypermobility and Craniocervical Obstructions in patients with ME/CFS (Pre-print 2019/published 2020) Bragée et al

    The NIH website classifies hypermobile Ehlers-Danlos syndrome as an inherited connective tissue disorder.
  12. Hip

    Signs of Intracranial Hypertension, Hypermobility and Craniocervical Obstructions in patients with ME/CFS (Pre-print 2019/published 2020) Bragée et al

    I found a diagram of CSF flow in Wikipedia: Flow of Cerebrospinal Fluid in the Brain and Spine The Swedish study by Bragée et al seems to be a bit of departure from the theories that Dr Fraser Henderson talks about. Whereas Dr Henderson focuses on strain-induced neuronal damage as the basis...
  13. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    It would be unwise for anyone to be convinced that they have ME/CFS, especially in the early years with the disease, when you are trying to figure out what illness you might have. Many conditions can mimic ME/CFS symptoms, and a diligent patient will consider and get tested for the most common...
  14. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    According to this article, 19% of neurosurgeons have to deal with one malpractice claim each year. It says that "the vast majority of these claims are resolved in favor of the surgeon".
  15. Hip

    Signs of Intracranial Hypertension, Hypermobility and Craniocervical Obstructions in patients with ME/CFS (Pre-print 2019/published 2020) Bragée et al

    But what's the point in being right if you don't get say "you see, I told you so"! It takes all the fun away if you cannot say that! One of the ideas some of us had when first contemplating craniocervical instability, Chiari and spinal stenosis in ME/CFS was that it could be the blockage of...
  16. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    The problem is that no information seems to be available online regarding the procedures and fusion hardware the NHS use in their CCI fusion surgeries. Therefore we have no idea what you would be letting yourself in for if you went to the NHS.
  17. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Are you not familiar with what is known as a doctor's sense of humour? Dr B has a great doctor's sense of humour, which has made me laugh on a number of occasions in his videos.
  18. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    "As far as we know" being the operative phrase. We don't actually know what evidence there is. So we cannot claim that there is none. We would need to do some further investigation into the subject matter. We don't know, but it may simply be by observing during his long career that fusion...
  19. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Yes, we had some debate about this, the excerpt from that video suggests that it's only vertical instability which symptomatically improves via cervical traction, but Jeff says that all forms of instability will improve by traction, and I think this may be correct.
  20. Hip

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    At timecode 59:00 of this 2018 video, Dr B talks about traction (pulling the head up), axial loading (pushing the head down), and cervical collars (which immobilize the head). Here are some quotes from Dr B: Dr B says in the 2018 video at 1:00:55: I actually know one ME/CFS patient with...
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