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My tentative and very speculative hypothesis (sorry if some don't like these!) is that Jen and Jeff's recovery may actually have been due to viral clearance brought about by the CCI/AAI surgery. In both cases, their POTS immediately resolved after surgery (POTS is objectively measurable). POTS...

I find speculative hypotheses very useful and thought provoking. If there are those who do not like speculative hypotheses, I suggest that's just personal taste. Some scientists are experimentalists, and like to deal with observation and empirical fact only. Others are theoreticians, and like...

I am reminded of Prof Paul Ewald's point of view, that the whole genetic causes of disease bandwagon has been vastly overplayed for decades. From Wikipedia:

I've a bottle of pure anethole, which I took internally at 12 drops daily for 5 months. I did not notice much, though it may have improved my IBS-D symptoms a little. Anethole though is not quite the same molecule as anethole trithione, so I am not sure if anethole has these antioxidant effects...

Yes I agree, ME/CFS is one of the worst diseases you can be hit by, in terms of the devastating effect is has on your life. If diseases were weapons, then ME/CFS would be an atomic bomb. But that's why I don't mind the term "mild", as even a mild nuclear explosion is a major event! Perhaps...

I cannot see anything wrong with using the term "mild". If you are a patient with severe ME/CFS, and confined to bed most of the time, then when you look at those ME/CFS patients who are still able to work full time and who are generally able to move about in the world, and probably still enjoy...

I wonder if using Ron Davis's technique of adding a salt solution to force cells to perform a workout would it be possible to model PEM in vitro? Davis adds a salt solution to cells because this forces the cells to generate energy in order to maintain the salt concentrations inside the cell. So...

This paper says that type I interferons both down-regulate mitochondrial gene expression, as well as inhibiting mitochondrial functioning. Thus if ME/CFS patients have elevated levels of interferon due to chronic low-level intracellular infection or due to dysfunctional immune activation, then...

Indeed! And to give the full Monty Python quote:

Yes, that's true, Wessely did not invent the idea of psychogenic illness, but I read an article years ago which explained the history, and that Simon Wessely single handedly resurrected the notion of psychogenic illness from its then moribund state. I can't find the article now (it may have...

But that is the history of ME/CFS, which is also an important story to tell. Wessely is the father of the "all in the mind" view of ME/CFS, and he played a fundamental role in turning ME/CFS into a condition that, from around the 1990s onwards, most medics started viewing as psychogenic. Before...

Are you perhaps suggesting that patients with pure endometriosis (whose symptom include chronic fatigue) might have been misdiagnosed as having ME/CFS?

Perhaps best characterized by his statement in 1994: "I will argue that ME is simply a belief, the belief that one has an illness called ME".

Thanks mango, I did not notice that there were Top tweets and Latest tweets tabs. I think that explains why I did not see my tweets, as I was looking at Top tweets. They do seem to appear under Latest tweets. Looks like under the Latest tweets tab there are hundred of tweets a day on #MECFS, so...

Did your tweets actually appear under the #mecfs hashtag listing though when you used this hashtag in your tweets? I see other familiar ME/CFS patients' tweets appear in the #mecfs listing, but my tweets never do. Perhaps I'm some sort of persona non grata on Twitter!

Whenever I've tried to use #mecfs on my Twitter account, it has not worked. I believe you have to be "someone" one Twitter first (I presume you have to have enough followers) before you can use that hashtag.

I am a bit confused then why F&M would include the response rate in the results section of the abstract of their 2011, 2015 and 2019 rituximab papers, if this response rate is not really that meaningful. Anyway, I always understood that the phase II results were considered positive enough...

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SUMMARY: Could the positive results of the early Fluge & Mella 2011 blinded phase II rituximab trial and 2015 open label phase II study be due to inadvertently including some Giardia lamblia ME/CFS patients in the cohort, from the 2004 Bergen Giardia...

Online ME/CFS forums should offer sufficient anonymity for such medics to post about having to keep ME a secret in their professional lives. It would be great if such medical professionals would join ME/CFS forums, and tell their story. Better still, it would be wonderful if these doctors...

Dr Chia's own lab is the only one which provides this enterovirus testing of stomach biopsy samples.