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@Sasha I think we need to check the primary outcomes. Marky90 was hypothesising about the actiometers

:grumpy: At least you've made me laugh a bit!

From what I gather, reading between the lines of Marky90's post, there does seem to be a responder subgroup even though the trial as a whole has been negative. I guess we'll just have to wait for the publication.

I should add that Fluge and Mella have sent letters to the participants.

Terrible news from Marky90 at PR: http://forums.phoenixrising.me/index.php?threads/rituximab-phase-iii-negative-result.56244/

For the avoidance of doubt, I don't think measuring fatigue is ideal, especially when the treatment isn't blinded but as ME/CFS has pointed out this is a preliminary study. @ME/CFS, many people have made suggestions about objective measures that you could use in a future trial. Can you say if...

All the patients you recruited were ill for more than five years. Of those who you considered responders, have any of them been able to resume their former occupations or studies or are they otherwise engaged in any activities that they were unable to do before treatment?

For me, the problem with ignoring fatigue is that it inevitably leads to even more fatigue and cognitive incapacity and if I continue to ignore that fatigue, then I can add pain and physical incapacity on top. It's difficult not to see the connection.

The SF-36 was also used. The author noted: This information could only have come from the SF-36 but I don't know how brain function relates to that questionnaire.

@NelliePledge I still can't type!!! See above

@NelliePlede re: NICE guidelines The minutes of the Forward ME group aren't public yet but they'll be available here: http://www.forward-me.org.uk/Minutes.htm

A few years ago, I would have put money on the former. Now, no chance.

https://www.merriam-webster.com/dictionary/nutraceutical

Gosh. She's just so impressively knowledgeable. Is there anyone on this forum who a) doesn't know what and where their femur is, b) doesn't know what an artery is? No? Thought not.

@dannybex and @Sid Did you know what your B12 levels before you started supplementing?

Are you getting your B12 levels tested first or are you just going to suck it and see (pun entirely intended).

Thank you @alicec :) Your theory about IF binding in the absence of TCN1 would certainly explain the high active levels. I haven't got around to looking at the links yet but shall study them when my brain is up to it.

When I was working, I'm sure there were times when people thought I actually was drunk because I fell over a couple of times, would often walk into the furniture and slurred my speech. I suspect that a lot of that was down to a combination of sensory overload and too much cognitive exertion. One...

I had a few blood tests done this week at a private lab and got some very unexpected results back. Before I give them, here's a little basic information about B12: There are three carrier proteins that are bound to B12 in the serum. When B12 is bound to transcobalamin I, also known as...

For all those who can't walk in a straight line, how's your Rhomberg test? Can you stand still with your feet a comfortable distance apart and your eyes closed? How about with one foot in front of the other as if you were doing tick tack toe?