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Following the section "A critical approach to the literature" :( is the section "Arguments for a functional disorder" — [34] is of course Interventions for the management of long covid post-covid condition: living systematic review (2024, BMJ)

Internal medicine at the crossroads of long COVID diagnosis and management Ranque, Brigitte; Cogan, Elie The lack of specificity in its definition is a major obstacle to both explanatory and therapeutic research in long COVID. It brings together, on the one hand, patients with severe COVID-19...

I was having a look through things in relation to Jo's comment here on NKs and MAITs. On MAITs, this recently revised preprint BioMapAI: Artificial Intelligence Multi-Omics Framework Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (2025, Preprint: BioRxiv) may be worth a look...

(Hospitalised, with severe acute COVID)

Sympathetic Neural Overdrive, Vascular Dysfunction and Diminished Exercise Capacity in Long COVID-19 Patients: A Long-Term Study of Cardiovascular Sequelae Bruna E. Ono; João E. Izaias; Artur O. Sales; Thais S. Rodrigues; Camila S. Nunes; Jessica F. Niec; Natalia G. Rocha; Helena N.M. Rocha...

From the introduction —

In the data analysis section (summary emphasis added) —

In the introductory section of this chapter, with some emphasis added for summary —

While the chapters in this book are focused on methodologies and directed at researchers, there are passages that are worth posting so we understand the data when presented. Here for example how to look at "high dimensional flow cytometry" figures.

I quickly asked my friendly neighbourhood AI that exact question (I didn't mention eg S100PBP) and got the following response. That suggests the reutilisation of genes in other tissues, that Jonathon mentioned recently. Although in this case maybe just different regulation rather than different...

LEF1 is Lymphoid Enhancer Binding Factor 1 LEF1-AS1 is LEF1 Antisense RNA 1 GeneCards — LEF1 LEF1-AS1

LEF1-AS1 Deregulation in the Peripheral Blood of Patients with Persistent Post-COVID Symptoms Madè, Alisia; Piella, Santiago Nicolas; Ranucci, Marco; Gaetano, Carlo; Renna, Laura Valentina; Cardani, Rosanna; Spinetti, Gaia; Milani, Valentina; Martelli, Fabio Long COVID denotes the persistence...

Particularly as it may well turn out that the answers for LC actually come from ME/CFS research (including DecodeME and friends).

Non-significantly higher in Self-reported health, neuropsychological tests and biomarkers in fully recovered COVID-19 patients vs patients with post-COVID cognitive symptoms: A pilot study (2025, PLOS ONE)

They also looked at BDNF, NfL and cortisol in plasma and serum, finding no group differences. Though cortisol was non-significantly higher in LC. LC Plasma = 81.38 Serum = 70.09 HC Plasma = 64.52 Serum = 61.29

Currently there are four, though I believe another group response may be inbound: https://www.bmj.com/content/389/bmj.r977/rr (Suzy J Evans) https://www.bmj.com/content/389/bmj.r977/rr-2 (Katharine A Cheston) https://www.bmj.com/content/389/bmj.r977/rr-3 (Michiel Tack)...

Thank you, that's both interesting and more than a little reassuring. My most recent employment eye assessment had also shown perfect retinal capillary appearances. The technique itself looks relatively straightforward and the only thing I'm unable to do currently is make measurements with a...

A response from the alternative medicine practitioners: Rebecca Kennedy, family medicine physician and lead of the long COVID clinic at a large health system :( That first sentence with the giveaway "CFS/ME". We've commented previously about the need for research into the psychology of...