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ME genome project. There was the human genome project, a big success. Now there is the ME genome project, hopefully also a big success. That's MEGP or MGP depending on how we abbreviate ME.

Will patients from outside the UK be able to participate? Have you considered working with researchers in other countries to reach the 20k target faster? Or is that not viable.

If the peak in teenage is due to hormones, and the peak in the 30's is due to something else, that might explain why there are two peaks.

I looked at how sex hormones change with age and it didn't fit the peak in the 30's well. If I remember right the hormonal changes are more gradual and occurred later. Of course you could come up with all sorts of ways to make is still fit, like thresholds. But it didn't seem to fit in any...

Is it because the biochemistry in every decade of life is distinct, and the biochemistry of people in their 30's increases vulnerability against ME?

It is not so easy to effectively communicate the situation we're in with less than 5000 words. You're touching an important angle here. The way things are currently being done does not work for us patients. What is required is a novel way to respond to problems like ME rather than building...

I think Science For ME should submit a response. Patients with ME and various other illnesses have been abandoned and a good way to change this is to invest in research to identify biomarkers and the underlying disease process...

Maybe in some patients the body reacts by trying to compensate with increased nutrient intake, in others maybe it reacts by reducing energy expenditure to a minimum.

I have the same reaction. Eating seems to compensate a little bit. My mental model of this was hypometabolism in the sense of lacking energy and trying to compensate for it, but it could also be thought of as hypermetabolism. Anyway the idea that there are changes in metabolism seem to be...

It seems to be a null result but the authors are trying to avoid that conclusion. This difference is just reaching the p=0.05 threshold. On other parameters the patients don't differ from controls.

I am now a participant in a genetics study :).

Can we rule out that psychogenic illness isn't merely a label for every as of yet undiscovered disease mechanism? Has it ever been definitely been demonstrated to exist?

Hard to believe that this is the same person that thinks ME is psychogenic.

I think they are suggesting that the energy metabolism problems might be a downstream effect of a problem affecting the purine metabolism.

What does this tell us about the illness?

Sounds like the real purpose of this event is to prevent meaningful patient engagement and ensure control remains in the hands of a few "experts".

I remember hearing during one of the recent conferences that there wasn't actually a difference between patients and controls. As far as interesting leads we seem to have: findings indicative of brain inflammation or abnormal brain metabolism, the observation that something in the blood is...

Depends. If a change in the microbiome is observed that correlates with improvement in symptoms, and the microbiome over time reverts back while the patient relapses back into a pre-FMT symptomatic state, I think that would suggest that the gut is very important. Assuming that there is proper...

A variation of the question above: if enough patients take part, would it be possible to recognize several subgroups from the data?

It is not merely arrogance. It is a deliberate tactic to discredit critics of his approach. First it misleads the reader into thinking that CBT for cancer is comparable to CBT for CFS. Then in effect he says that critics object to CBT for petty reasons. I suppose that makes him arrogant in the...