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Wow that's a lot of responses. I counted 328 pages of responses in total. Some are thoughtful, some are weird. Either way it shows a great public interest. PS: a very rough estimate is 8 responses per page, or 2624 responses in total.

I agree that we need the narratives about ME to accurately reflect the science. If we actually do this then almost all the narratives that circulate fall apart. The narratives that purport to explain what ME or CFS really are, what they are caused by, and how they can treated.

It's a bit like the PACE authors who justified outcome switching by saying it made the results align with previous studies and their clinical experience (or something along those lines). It would make a lot of sense to me if there was some energy generation problem in ME/CFS but accepting false...

As far as I understand: What is happening with kynurenine and cancer cells with mutations that lead to a highly active kynurenine pathway can escape destruction by the immune system because activation of the kynurenine pathway has a local immunusuppressive effect. There are attempts to develop...

They are curating their image of being the authority on interpretation of clinical trials. Everyone should know Cochrane stands for expertise and quality :D:rofl:.

How far away is a diagnostic test? Even one that merely shows something is wrong and is usable in practice by physicians would be a nice step forward.

I would like to know what other illnesses have similar metabolite profiles, and whether he feels confident to say anything about metabolism in ME/CFS yet.

I am very interested to hear what he thinks about Fisher's findings.

These are the five factors which as I understand are multiplied and then divided by 0.182 to obtain the mitochondrial energy score (so your calculations would be incorrect). Here are these five factors, together with the CFS ability Scale scores.

The mitochondrial energy score is constructed from several different measured parameters. Maybe that's why it doesn't look like a natural thing, because it's a human construct. Edit: I'm inclined to agree that very low mitochondrial energy scores are suspicious because it implies that in the...

I'm reading one of the papers on the test now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/ They write It doesn't specifically say that the delay between blood draw and testing was the same for both groups. If the authors believed that it wasn't relevant, they wouldn't consider there...

The authors of the present paper have some data that suggests cells change over time. It's hard to understand the technical details but the meaning is clear. If the Myhill group used as controls samples that were fresh, while patient samples were shipped by mail and at least 24 hours old, that...

One way to look at the situation is that patients were being sold an expensive test that isn't fit for purpose. Maybe the replication attempt is flawed and the test works but it's not a good sign that there is disagreement. The possibility that the test isn't fit for purpose must be seriously...

I think that's the highest prevalence estimate I've ever seen. Therapists will be pleased they can now potentially give CBT/GET to many more people, or at least that seems to be the goal here.

Yes, mass hysteria is not just panic spreading through a group. It claims to explain all sorts of symptoms that are difficult to explain with panic or exaggeration. To me a more plausible explanation is a combination of panic spreading in the presence of some physical cause of symptoms. If for...

In an alternate universe (maybe this one too), in Malaysia a group of wise men are explaining in the press how demonic possession produces real symptoms that are often mistaken for mass hysteria. They also talk about the stigma of demonic possession and how this leads to people being overly...

A not entirely authentic outward optimism with doubts that are never expressed? They want to believe, but testing CBT/GET in a properly controlled clinical trial is too scary because they know it might not actually work.

Do you think that CBT/GET proponents know this treatment doesn't work but pretend to honestly believe that it's effective?

They're in a loop trying to save their latest dishonest statement with more dishonesty and it gets less believable every year. In their response to Wilshre et al, Sharpe was essentially claiming that they have found a method to eliminate the issue of biased reporting in questionnaire-based...

Thanks. Do you know if Soares-Weiser believes the scare stories about patient activists?