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I wonder if it is intentional to makie receipt of disability benefits depend on the completion of a treatment that is known to be very difficult for patients to complete.

Do the medications cause fatigue or reduce it? I know almost nothing about HIV but I have the vague memory that one or some antiretroviral medications used to treat it cause fatigue, perhaps by interfering with mitochondrial function.

Paul Fisher thinks he's found something.

I am constantly going from "a little bit of spare energy" to "exhausted" despite already reduced activity levels. Maybe there are two problems. One is a relatively minor energy production issue that produces short term effects in the timeframe of hours and this makes patients think that they...

If most of the body's energy production goes toward merely sustaining itself, then even a small decrease in ability to produce energy would mean a large drop in ability to function in daily life. If for example 70% goes toward sustaining itself, and 30% towards daily activities, then even a 10%...

How dystopian. Never mind increasing poverty, inequality, defunding and privatization of healthcare. Think positively. That will make you live longer.

That PEM preferentially kicks in overnight is I think a clue that it's related to housekeeping processes that occur during sleep.

I don't mean a gradual onset PEM, just the phenomenon where a certain dose of exertion is tolerated if preceded and followed by days of low activity or rest, but not if repeated several days in a row. There seems to be something like an "energy debt" that can accumulate. Whatever it is that is...

Here's my mental model of PEM. This seems to be able to predict several important qualities: the ability to accumulate an "energy debt", the delay in onset of PEM, the delayed recovery. The "Signal" is whatever it is that ultimately pushes the body into PEM, which could be something like a...

This is roughly how I think about it. Exertion is a bit narrow as there seem to be other less obvious things that also affect the orange curve.

I think we concluded that this was a misunderstanding.

So maybe PEM has something to do with TSP-1 going up and acting as vasoconstrictor. There's also some literature on how it activates TGF-beta (the one cytokine that stands out more than the others in ME/CFS).

Does their illness model reflect how they see patients? Or does it reflect their intellectual level? The level where correlation and causation are a difficult concept to comprehend.

It is definitely not the heart rate, otherwise all the people with POTS and ME would be in big trouble, and the people with ME and a low heart rate would be protected. I think it could be the result of a tipping point reached due to a faster accumulation of x due to deficient mechanisms to...

The Hyland model is just a rephrasing of the CBT/GET model. Applied to fibromyalgia patients though. This explanation isn't very clear but it sounds like stopping activities due to symptoms is considered a faulty behaviour. Or maybe that's your interpretation and these lifestyle...

The Wilshire paper should have sunk them, but instead their colleagues closed ranks. It seems that psychiatry is more interested in protecting their profession than making the world a better place. If people outside of psychiatry cared about ME this would be different.

The unambiguous official recognition is probably worth a lot more than $1.4 million because it makes further gains in various areas easier to achieve.

Yes, the health minister clearly gets it and researchers that spoke too. The patient was great too!

It works fine for me. The livestream is up, but the event will start in a few minutes. It will be in both English and French according to the chat participants.

Her mitochondrial energy score test just failed an independent replication.