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What @adambeyoncelowe said. I think Wessely and maybe some of the PACE authors and colleagues have repeatedly claimed that neurastenia and ME/CFS are the same, and I think that isn't grounded in science but a politically motivated form of illness denial. If a psychiatrist believes CFS and...

It seems they've set things up so they cannot fail. They will be able to show modest positive transient effects over a no treatment control on the first try, for any condition, and they will interpret them as evidence of benefit. The transient nature of the effects will be interpreted as...

What does "mediated" really mean here?

Basically I think we need permanently funded research centers that are highly focused and knowledgable about ME/CFS and have the explicit mission of developing a diagnostic test, treatment, prevention, etc.

I think the way research is funded may make sense for some problems but not for others. Research projects try to formulate a simple question and then answer it. The idea seems to be avoid putting money into overly ambitious projects. The results can then be published and replicated and then...

@ScottTriGuy how did you Canadians achieve so much positive change in relatively little time?

I have the suspicion that some symptoms associated with upright posture are being neglected. We focus on measurable things like heart rate and blood pressure that have a relatively clear trigger, but I think that I've had subtle orthostatic intolerance for a long time, possibly since illness...

This is the kind of articles the PACE authors are trying to make appear.

The tilt table test is also used to diagnose POTS. Do you have symptoms consistent with POTS? From https://www.nhs.uk/conditions/postural-tachycardia-syndrome/

This is the important part. The data shows that current or past psychiatric illness may be associated with worse illness measures but the effect is too small to survive correction for multiple comparisons. This suggest that viewing CFS as manifestation of depression/anxiety is largely...

How medicine deals with patients that have unexplainable symptoms needs to change. Currently the answer is ignore, downplay and psychologize. Not just with ME/CFS but with many other health problems. What they should be doing is acknowledge, admit that nobody has answers, and send patients to...

MUS theories are hate and prejudice disguising themselves as scientific theory.

I am excited.

What homeopaths should be doing is not expensive clinical trials on humans, but small and inexpensive experiments on say plants that can convincingly demonstrate that the homeopathic remedy isn't just water. That would demonstrate that there is something to the idea.

I am convinced that there is a problem with diagnostic confusion and unreliable claims of treatment efficacy. I am not convinced that we can rely on anecdotes to determine that some treatment helps some particular group of patients but not some other group (lightning process helping...

Yes it would make sense. I think patients are put off by this kind of psychiatry because they can sense that something isn't right. The CBT/GET people probably interpret this refusal as patients not wanting to admit that they have a "psychosomatic" problem or fearing the stigma of psychiatry in...

One important difference between a snake oil salesmen and CBT/GET proponents is that the latter have political power which allows them to get away with low standards. CBT/GET people are also good at marketing.

Looking at the graphs showing how different doses affect various aspects of rat physiology and behaviour, this does not look promising. The greater water retention (delayed urination) could be generally desirable in ME/CFS. An increase in maximum heart rate also, but only if the resting...

I'm not really following the situation in Italy but some guidelines were published a few years ago. I don't know if they are still considered up to date or to what degree they influence care. The document mentions Cochrane as source of information but doesn't seem to cite the "exercise therapy...

It seems inherently difficult to accurately measure improvement in the condition and determine whether that is due to the clinic. Anyway, I would like questions that aren't about how I feel but about what I'm able to consistently do.