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The adolescents with Paediatric ME and CFS had slower reaction times before cognitive exertion and even slower after exertion. That could be key. Also in adults. In my case I noticed the more severe I became the slower it was. It graduly improved with taking the immunemodulator. A while ago...

And dismission.

In conclusion, microglial activation during prion disease progression is a complex and multistep process, with activated microglia comprising a heterogeneous population with diverse functions. At early stages of prion infection, microglia respond to PrPSc deposits and consequently increase their...

https://www.ncbi.nlm.nih.gov/pubmed/28714865 Microglia in prion diseases. On the positive side, recent findings suggest that therapeutic strategies modulating microglial activation and function may have merit in prion disease.

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. bchesebro@niaid.nih.gov. https://www.ncbi.nlm.nih.gov/pubmed/30650564 Neuroinflammation, Microglia, and...

Search for prions (prpsc) and inflammation. In the beginning there was consenses there was no inmunneresponse. Now it is a different story.

Well, I had those and still get the limbweakness during flairs. I think it is the meninges doing its job that causes signal problems in the brain.

If one did not show depression it was assumed it was hidden depression.

If he wanted to help he would not have made all the ridiculous claims.

A very very long time ago (before I fell ill) I had an encapsulated blood shedding. It stayed for decades but in the end it disappeared. After a while it did not hurt anymore. It just was present as a bump.

The meninges has sensors.

I agree.

Yep

It feels like inflamation. I do not have a good discription but when you get it you will know the difference.

Maybe she means by lungs closing up what I had. For the swelling, there was a time my calves could become twice as thick overnight. To the touch it did not feel like edema.

https://www.zora.uzh.ch/id/eprint/136313/1/PhD_Thesis_Despoina_Goniotaki.pdf @InitialConditions What do you make of this? Can we learn something from these people? Aguzzi is a prion expert and looks further then the tip of his nose. Weissman is one of the pioneers.

I get these too. I think they are related. After many years observing I think I know the sequence. First the not moving pain ( can be at several places ), then the shooting from the inside to the outside, then something expelled through the skin, then the itching without redness.

Couldbe either or all. I stopped wondering.

You describe it well. Mine go from the inside to the outside. Can not be an insectbite. With overall improvement it gradually became less severe. Did you notice sometime after the shooting it starts itching?

:emoji_grinning: