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    Intra brainstem connectivity is impaired in chronic fatigue syndrome, Barnden et al., 2019

    I think connections working less good. With the pathogen I suspect the brain problems start when the synaps transmission is affected.
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    Fatigue in inflammatory rheumatic disorders: pathophysiological mechanisms, 2019, Korte and Straub

    Sixth, astrocytes produce kynurenic acid that acts as an antagonist on the α7-nicotinic acetylcholine receptor to inhibit dopamine release. And levamisole is an allosteric a7nAchr modulator
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    Solve ME/CFS Initiative: Ramsay Grant program 2019 awards

    https://ashpublications.org/blood/article/104/2/478/18286/Peripheral-CD4-CD8-T-cells-are-differentiated IMMUNOBIOLOGY| July 15, 2004 Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions Michelina Nascimbeni , Eui-Cheol Shin , Luis Chiriboga , David E...
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    Solve ME/CFS Initiative: Ramsay Grant program 2019 awards

    https://www.nature.com/articles/s41598-017-11926-2 Moreover, we showed that a greater proportion of CD4+CD8+ T lymphocytes have an enhanced capacity to produce cytokines (IFNγ, TNFα, IL-2, IL-4, IL-17A) and lytic enzymes (perforin, granzyme B) compared to CD4+ and/or CD8+ T lymphocytes.
  5. L

    Is ME a metabolic problem or a signalling problem?

    Yep My breathing became worse and worse. It is much better now. I am pretty sure the problem was caused by malfunction intercostal muscles, the pleura and diafragment. The automatic breathing system was impaired.
  6. L

    Intra brainstem connectivity is impaired in chronic fatigue syndrome, Barnden et al., 2019

    When corresponding correlations from HC and ME/CFS were compared, ME/CFS connectivity deficits were detected within the brainstem between the medulla and cuneiform nucleus and between the brainstem and hippocampus and intralaminar thalamus, but only during task. Could fit.
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    Researcher Interactions Video: Science for ME Q&A with Dr Michael VanElzakker, Oct 2019

    It are both Acetylcholinesterase inhibitors but not the same.
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    Researcher Interactions Video: Science for ME Q&A with Dr Michael VanElzakker, Oct 2019

    I can see why he things that but decades ago I decided not to go the galantamine route.
  9. L

    Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent, 2019, Wolf et al

    Altogether, our data support a new model in which cristae within the same mitochondrion behave as independent bioenergetic units, preventing the failure of specific cristae from spreading dysfunction to the rest. Interesting.
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    Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent, 2019, Wolf et al

    There are many mitochondria in one cell scientists generally agree that the mitochondria in human cells come from bacteria that were incorporated into primitive cells about 1.5 billion years ago.
  11. L

    Lactate dehydrogenase supports lactate oxidation in mitochondria isolated from different mouse tissues, 2019, Young et al

    Lactate serves as a substrate for H2O2 production. H2O2 can destroy pathogens.
  12. L

    Abnormal blood lactate accumulation during repeated exercise testing in ME/CFS, 2019, Lien et al

    In conclusion, previous exercise deteriorates physical performance and increases [Laa] during exercise in patients with ME/CFS while it lowers [Laa] in healthy subjects. That is clear then. The normal rules do not apply to patients. When will Wessely and co understand that?
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    Resting-state functional connectivity, cognition, and fatigue in response to cognitive exertion: a novel study in adolescents with CFS (2019) Josev

    https://www.s4me.info/threads/why-does-levamisole-help-me-mitochrondia-a7nachr-tryptophan.11324/#post-202639
  14. L

    Resting-state functional connectivity, cognition, and fatigue in response to cognitive exertion: a novel study in adolescents with CFS (2019) Josev

    I think that makes it worse. To much strain. I just let nature take its course and my insommia disappeared with overall improvement.
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