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    Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients - Ovejero, Oltra et al Dec 2019

    No known pathogen that can be tested for.
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    The role of low-grade inflammation in ME/CFS (Chronic Fatigue Syndrome) - associations with symptoms, 2019, Jonsjö et al

    Do not know but if sickness response is seen in animals they must be kept as stressfree as possible. The advice can even go as far as put them in a dark quit place.
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    The role of low-grade inflammation in ME/CFS (Chronic Fatigue Syndrome) - associations with symptoms, 2019, Jonsjö et al

    I would say something causes a prolonged sickness response and the clinical picture is called ME.
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    "ME/CFS Funding Worsens As NIH Maintains Status Quo"

    :emoji_clap:
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    "ME/CFS Funding Worsens As NIH Maintains Status Quo"

    I was not. Have been waiting for it.
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    An Alzheimer treatment: lecanemab (Biogen)

    Amyloid is only part of the story.
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    Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (2019) Karhan, Unutmaz et al

    I am interested in the MAIT cells and interferon gamma. There seem to be difference between patients and controls. Do I see that correct?
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    Pain Catastrophizing Affects Stair Climbing Ability in Osteo Arthritis (2019), Suzuki, Y et al.

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    Alpha-7 nicotinic acetylcholine receptor literature

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687317/ The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials The alpha-7 nicotinic acetylcholine receptor (α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca2+-permeable ion...
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    Alpha-7 nicotinic acetylcholine receptor literature

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894934/ Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders Notably, the anti-inflammatory response to α7 nAChR stimulation also occurs in the brain. Thus, activation of α7 nAChRs is known to alter the phenotype...
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    Action CIND Webinar: "Why Working out Doesn’t Work" by Workwell Foundation

    I think the leg problems are important. I still have some. When I was much worse it happened my legs suddenly refused to carry my weight.
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    How to explain the 'fatigue' of ME/CFS to non-sufferers - comparisons they could understand

    Yep
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    A neuro-inflammatory model can explain the onset, symptoms and flare-ups of ME/CFS, 2019, Mackay

    Recently I catched someting from a visitor. Seemed a cold and many cold bugs are going around here but no influenza virus yet. It started like a cold but then the immunesystem went after the mysterious chronic infection causing a nasty flare. As always no real fever. I am still not fully...
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    Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (2019) Karhan, Unutmaz et al

    I do not want to.
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    How to explain the 'fatigue' of ME/CFS to non-sufferers - comparisons they could understand

    I agree
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    How to explain the 'fatigue' of ME/CFS to non-sufferers - comparisons they could understand

    Not me. It is overwelming and can come up in a second. One strange thing I noticed. When I rested in a flare, just lying down on the sofa. Suddenly the overwelming fatique started and very fast spread to surrounding tissue.
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    Ron Davis latest: more evidence of "something in the blood" (Simon M blog)

    https://en.wikipedia.org/wiki/Bistability In biological and chemical system Bistability is key for understanding basic phenomena of cellular functioning, such as decision-making processes in cell cycle progression, cellular differentiation,[5] and apoptosis. It is also involved in loss of...
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    Junk food 'should be labelled with how long you need to exercise to burn it off'

    Yep and as I observed it can change during the course of a disease.
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    Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle

    Yep
  20. L

    Do Acute Exercise-Induced Activations of the Kynurenine Pathway Induce Regulatory T-Cells on the Long-Term?.., 2019, Koliamitra et al

    Healthy female participants
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