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I can't see a scenario in which the rest of us get nothing. Non-rich people with MS don't get nothing. The country can't afford to have so many of us economically inactive. And our families want us back. All hell would break lose if PwME weren't treated if an effective treatment were available...

Still thinking about the cure! And with the UK as an example. Suppose an effective drug treatment is discovered and gets approved for use in the UK tomorrow. We know we've got hundreds of thousands of PwME in the UK, some in utterly dire straits (including some of us on this forum), all of us...

Two parts to this question, really: (1) If a cure, or just a better treatment is found for any disease, do GPs reach out to their patients to tell them and to invite them to get the treatment? Would this happen for MS, RA, etc.? Did it happen when the NHS wanted to switch people with asthma to...

Ordinary N95 masks seem to be called 'respirators', which confused me because I initially thought of a respirator as essentially a gas-mask. Here's a photo.

I only found out about it about a year ago and was horrified that this risk isn't made known.

Note that there are no customer reviews on Amazon yet, as the book only came out yesterday, so there's an opportunity to set the tone and do some consciousness-raising.

It's also available as a Kindle book, although I don't like to read nonfiction on a Kindle because I can't highlight things in a way that makes it easy to refer back to them.

Congratulations on your 20,000th message on S4ME, @Jonathan Edwards ! :balloons::balloons::balloons::balloons::balloons::balloons:

Well done, @Tom Kindlon - that standing ovation was well deserved!

Amazed that nothing better than the existing supplements are on the market. It's currently endless self-experimenting for all patients to find the least horrible.

You can buy DAO in supplement form.

:banghead: But is anything stopping you from comparing females with males?

Just picked up the latest copy of MERUK's Breakthrough magazine and there's what seems a very relevant study by a Dr Manousaki starting up: Chromosomes carry our genetic information and, typically, females have two X chromosomes while males have one X and one Y chromosome. In females, one of...

I don't understand - if the sex ratio is the same in both cases and controls, you're not comparing equal numbers (because controls vastly outnumber cases in a GWAS) but you'll be comparing males and females in the same ratio. So if you've got 7,500 female and 2,500 male cases and 75,000 female...

All our evidence seems so feeble that I don't have a sense that we even have many definite negatives, let alone definite positives.

Aren't all GWAS control samples selected with the same sex ratio as the disease group? Would a WGS study also help look at this, because it can detect repeat segments (i.e. extra dosing of the gene)?

If that was so, wouldn't TLR7 have shown up on a bunch of GWAS by now?

I think you could still 'yellow card' it?

If you can't sample the bone marrow in a useful way, how could you test your theory?

Thanks very much indeed for trying. That's quite worrying, though, that you had no response. Unless they've got social media, it seems the only possibility of direct contact is to donate and use the comments facility on the donation page - with no guarantee that they would read it, and of...