Search results

I think otherwise, in quite a major way! I'm really excited about your and Jo C's paper but when it appears, as things stand, I really am going to be reading it thinking, 'What? What?' Like @hotblack, I've been mugging up on DNA (thymine! homologous! SNP!) so that I have more than a snowball's...

Do you foresee other kinds of drugs being effective that wouldn't have this kind of downside, as per your upcoming paper about your theory? Just wondering also when you're hoping to post your theory - I think we're about three weeks into the month you estimated but plans go to hell as soon as...

The pandemic is never going to go away, in essence, for all that people refer to Covid now as endemic. Does this drug block people's ability to respond to infection as well as to vaccination? Either way, can this drug ever be safe now?

I am basically at the level of, 'Ooh, look! Genes!' so don't feel bad.

It's horrifying, honestly. A friend has it done and it's £70 a pop and he needs it doing several times a year. His ears really hurt when the wax gets impacted. What are people with no money supposed to do?

Machine learning? Thanks! It's exciting, then, to think what this approach might come up with if you shove all the 20k PwME from DecodeME into it, rather than the 1k here.

I'm amazed that anybody is getting their earwax removed on the NHS, let alone in a hospital. GPs won't do that where I live - people have to find a private practitioner.

I've been assuming that DecodeME will just pull out as interest-worthy the SNP differences between cases and controls that cross a certain threshold for statistical significance, with each SNP being treated independently in statistical terms from the other SNPs. But it sounds as though the...

It depends on the research but sometimes researchers want to do quite fine-grained stuff, in part because the narrow area where you live would give a proxy for socio-economic status. Doesn't mean they need your entire postcode, though. But still, a partial postcode combined with other stuff...

One of the options was biomedical research to lead to effective treatment, though!

For geographical analysis.

Maybe it has - we don't know that people haven't been put off the field in droves. This is a different issue, though - it's a fundamental design issue that's being ignored. It's a big fat emperor with no clothes on but there's no little boy pointing it out. I agree, but I wasn't suggesting...

Hard-line BPS people seem to defend themselves against rational argument by simply not engaging with it, but they would not be the most important audience. Such a paper could save early-career psychologists from falling down that rabbit-hole; it could alert the medical profession more widely to...

Even that's not very close. I think we need a 'BPS trials are rubbish and here's why' paper.

I've been thinking how useful it would have been during all this to have had a factsheet on why BPS trials produce results that can't be trusted, and that explicitly tackles the profoundly illogical things that proponents say to defend those results (such as 'You can't do unbiased trials...

You're right, it doesn't - I misread the abstract and thought it said that the HBOT showed 'no more than' short-term benefits, rather than 'showed no more benefits'. o_O

Way to not get your research taken seriously.

Would the placebo have been adequate? Would people have been able to tell whether they were getting normal air, rather than oxygen? Edit: And low pressure rather than high pressure air?

They aren't biomarkers but ME/CFS is significantly disabling and so activity levels would be expected to be a reasonable proxy. The NHS classes 'mild' ME/CFS as follows: 'You’re able to care for yourself but may have problems moving around; you may be able to go to work or school, but will not...

No, it had a statistically significant reduction in self-reports of fatigue, but not in self-reports of physical function, and the reduction in self-reports of fatigue wasn't maintained at follow-up. I genuinely don't know why you continue to treat subjective measures in open-label trials as...