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But isn't whole genome sequencing fishing for rare SNPs?

I think that raises the question of 'why not', though. If a small, deep-learning study spits out lots of statistically significant genetic associations, do we take them seriously or not? If we have to wait for better information, is this information not reliable? And if it isn't, what's the...

That seems unlikely, given that that team seem desperate to get answers for PwME as soon as possible. I wonder if they want big numbers to go for a classic approach because deep learning models might not be trustworthy. They seem very black box. I worry that we might overlook the opacity of the...

SequenceME intends to examine the DNA of up to 17,000 PwME with whole genome sequencing, presumably because they think the big numbers are necessary in order to give a useful signal. I don't understand much about what's going on in this paper but can we trust results based on only 247 cases?

Thanks so much to everyone for their hard work on this. So exciting to see the factsheets getting translated!

Big thanks to everyone who has helped with the translation. Really exciting to see it! :thumbup:

Good luck, @josepdelafuente! :thumbup:

Just wondering how the paper is progressing? I have the impression it has been getting bigger/more involved!

It never used to happen, so unless I suddenly became pleasant about twenty years ago, perhaps it reflects some new fashion in UK medicine, like how GPs suddenly started shaking hands with patients (until Covid).

Sorry, I haven't been following the thread! Do you feel we're further forward with understanding what they found and what its implications are?

It's been a week since you submitted your comment and it's still not up. :(

From what I've read on the forum (possibly this thread), high-quality biomed researchers are having their proposals turned down by BPS proponents who think there's no need for biomed research. I don't blame those researchers for not bothering to submit proposals in such a situation. Don't we...

Whether our model for progress is a research hub or a bunch of maverick geniuses, is it right to say that the problem is the rubbish assessors at the MRC? A situation that Stephen Holgate has been trying to fix for twenty years but hasn't? Then shouldn't all our efforts be focused on the...

:thumbup::trophy@

You've surpassed me - I only ever made it to 'pleasant'. :whistle: Yikes.

This is interesting - I've had this in my clinic letters and I thought it quite weird. It seems to be mostly neurologists who do it. I wondered whether they're just generally trying to appease patients as standard. I'm lovely, of course. :angel:

Thanks - that's all very interesting. I had thought that that red cell deformability stuff had gone in the bin. Can we do anything to help make this study happen?

Why is this worth looking at in PwME whose ME didn't follow Covid? Isn't all this microcirculation stuff likely to be quite Covid-specific?

@DMissa, if you want rapid feedback on your draft, I'm sure there would be people willing to help here, and if you wanted it to be private you could get the feedback via a group PM, for example.

Given that you're working on an extremely short timeline, you're not going to have time to read and synthesise tons of papers if your aim is simply to summarise the evidence on efficacy and risks. So on efficacy, I'd focus on the trial design issues: namely, that in open-label trials, all...