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As I posted some time back: I'd try this now but I'm much older and would be scared about having a heart attack, plus I'm too feeble to get out of a bath now...

FWIW, I had a massive remission ten years in, going from bedbound to able to work full-time and live a largely normal life. In retrospect, there were red flags but I'd call it a big fat remission. After some years, I relapsed.

The treatments considered at the end of paper all seem like heavy-duty immune drugs, to treat the upstream problem. We're likely to be waiting a long time for them, and they might not be suitable for some, plus there might be concerns if they're immunosuppressive, in this time of endemic Covid...

@Jonathan Edwards, I have been reading :emoji_hotdog: that as we get into old age, our immune systems get weaker, including T cells forgetting antigens. Would your model predict that PwME would get better in old age? Do we know whether PwME do in fact get better in old age? (We'd expect some...

Struggling to remember what has gone on already so someone may already have raised this but could the two types of ME/CFS (synapse-maintenance vs T cell function) be why there are two age-incidence peaks for ME/CFS? One peak for each type, due to... stuff? @Simon M [Edit] Was this idea in the...

:arghh:, given that I'm about 40 years in. Does this happen in RA and other diseases (assuming they're the sort of bistable thing you're talking about) - namely, that the longer you've had it, the harder you are to treat and the less likely you are to go into remission, especially long-term...

Thank you anyway for your concern, @AliceLily! It was a joke in good part which I enjoyed and those buns got me a really long way. I recommend the book (though others here think it a bit inaccurate). :)

No, not at all! It's a joke about how I've been mugging up frantically in preparation for publication of this paper by reading the Kurzgesagt book, 'Immune', in which Major Histocompatability Complex Class II molecules are compared to hot-dog buns that present antigens (the 'sausages' in the...

For me! For me! Not for the paper! :nailbiting:

The hot dog buns, surprisingly, got me all the way to the synthesis where things fell apart considerably but I know now that I can build on the buns! I may be some time...

:trophy@:trophy@:trophy@

Just started on this, armed with my knowledge of hot-dog buns, but already enjoying the 'A little more T-cells' quote at the start... Thank you so much for this, @Jonathan Edwards, Jo Cambridge and Jackie Cliff.

I hope that this isn't the week that Qeios has chosen to collapse.

Well done, @dave30th - and very sorry to hear about Mady Hornig's experience.

They put them all out this morning and then packed in for the day. :(

No. I didn't say that or imply that, and it's not what I think.

Where's the paaaaaaapeeeeeeeeerrrrrrrrrrrrrrrr??? :arghh::arghh::arghh:

I would hate to think that the Murder University of the Thymus wasn't real...

TBH, I was already wondering if dendritic cells don't really present antigens in hot-dog buns... :whistle:

When I'm waiting for something like that, I like to think of sleep as time travel - close my eyes and it will instantly be seven hours later...