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I was hoping to get an auto-transcript from YouTube and run it through Google translate, but there seems to be no transcript. However, by mucking around with Settings (the little cogwheel thing), I'm now getting subtitles in English via some sort of live auto-translate thing.

Did you say something on another thread about daratumumab being not an ideal treatment choice (as opposed to a test of principle) for some reason? Because it's cumbersome or risky or something? I might have got this wrong.

A good question, but one for another thread, maybe!

I'd been hearing about that work a few years ago, and it seemed to be a real mixed bag in terms of opinions about how effective they would be. Does anyone have a sense of how promising they are, even conceptually? I thought they were already in use in some countries but I haven't followed the...

That's extremely good news. When people on immunosuppressive drugs, such as people with RA, attend hospital or a GP surgery, are any precautions taken to protect them from infection, or is that risk treated with the total disregard that it is for the rest of us? I've never understood the lack...

Does rtx increase cancer risk because of the immunosuppression, and if so, do we know by how much?

I've been asking on another thread about the implications of being treated with immunosuppressing drugs if @Jonathan Edwards's ideas about the mechanism of ME/CFS are correct and these are the drugs that we end up on. In a world of endemic Covid, being immunosuppressed will presumably be an...

What happens in RA, for example? Are people on rituximab constantly? (Or is RA not a good comparison?)

No! Symptoms of post-exertional malaise are a risk factor for high information-seeking. :banghead::banghead::banghead:

@Jonathan Edwards, you said on the pre-match thread, when I asked if all the likely treatment drugs would be horrible: You mentioned a while back that endemic Covid had changed the landscape of using (I think) the -mab drugs. Would that apply to the ones that you're thinking about, and that...

I wonder if the lack of highly sedentary controls could be a problem here. I haven't read the paper but from a quote above: I don't think that matching for BMI is necessarily enough. I have a normal BMI but have lost muscle and gained fat, due to my extreme inactivity. One of those fancy...

Can people who don't have an institution address post a comment on Qeios?

People's mental models of what is going on can be very powerful, though. We read all the time about new PwME who didn't trust their own experience of decline and got repeatedly pushing into overdoing it.

I've been thinking some more about this. I think an explanation would be useful for PwME, because the dominance of the BPS model - likely to continue for some time, especially if this is what your immunology colleagues think - mean that we'll need to defend ourselves against this kind of...

Doesn't reflect well on that scale, then.

A lot of these are sounding fairly horrible and potentially quite dangerous, given their immune-suppressing properties. I'm wondering whether there's a non-horrible view of our future that doesn't include continuing to have to shield (I've been shielding for five years now).

I think that's an important argument to present, though, but rather than being part of this paper, it should be a standalone?

Similar issue for me.

Are there any implications of the model for vaccinations, either pro or con? I'm wondering if it means that more severely ill people are more likely to react badly to vaccines.

It was a real shame that Prof. Kakkar never did the clinical trial he promised. We hear of PwME doing cryotherapy, with anecdotal success IIRC. Do we have trials of cryotherapy? Is there anything similar we could do without the heart-attack risk for those of us now knocking on a bit?