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It's possible to comment on the manuscript.

Certainly it's getting no shortage of attention - it's had over 6,500 views and has been downloaded nearly 1,000 times. Hopefully, some people are starting to think about empirically testing some of the key ideas. Do we know if anyone has started work? (People may have said so on this thread...

The preprint has been up for two weeks now and still no reviews. Is that weird? Or is all the reviewing happening on S4ME, with no one left over for Qeios?

Welcome to the forum, @ScoutB!

I'm sorry to hear he was ill. Thanks for trying, on the Neil Riley issue. I can't see any trace that Dr Shepherd has ever posted on S4ME, but he made 2,000+ posts on the old forum up until August 2018. Maybe he never made the move here. Maybe this is a big part of the problem - that people from...

Can Dr Shepherd by called on to get this taken down, given the threat to all our credibility? If the science comes along this year as you expect, to give a clearer picture of what's wrong with us, do you see this 'alternative reality' problem as being solved? Or do we need to think of ways to...

If BPS proponents are confused about this, then a lot of PwME are probably confused about it too (me included, obvs). I think we should discuss it so that we can understand it, so that we can communicate about the new theory in a way that doesn't hurt us. If our only defence to, 'You can push...

But even if you don't equate our consciousness with an 'I', surely there is something with within us that has intention and is making decisions? If not, how come my fingers are moving across this keyboard to type a message?

My armwaving 'etc. etc.' was really meant to indicate anything that we might normally think of as the energy production aspect of the cell (but maybe that is just mitochodria - I don't know!), as opposed to signalling. This really confuses me. Surely I can, under normal circumstances, tell my...

From the paper: I don't understand the principle of action of the therapeutics proposed in the paper well enough to tell whether they're targeting mechanisms downstream of these homeostatic controls. Is there potential to get the homeostatic controls to kick in better, rather than trying to...

I am confused in (I think) a similar way to @Simon M here. If I'm understanding correctly, you're saying in your paper that some signalling is going on that's telling a PwME that they're exhausted, even when the mitochrondria are fully charged, etc. etc. I don't understand why we then can't push...

Huge thanks again, @Jonathan Edwards, to you and your co-authors for this paper. I've just been reading the 'Synthesis' section of the new version, where no bun dares to go, and have a few minor editing suggestions: p. 12, para 2: 'However, for antigens to which high-affinity antibody is...

Can anyone provide me with a link to this poll, please? I wasn't able to find it on a search.

Our charities seem to go through phases, and in the bigger ones, there seems to be a constant bubbling up of BPS stuff while at the same time, the charities are promoting bioscience and trying to get it funded. That suggests to me a mix of different people holding different views. How much in...

I doubt that chronic overheating or chronic overcooling is the answer - but as for cryotherapy, maybe a short, sharp dose is the thing to test.

Audrey did standard science (cases vs controls, but with fancy tech), whereas PL did something that I think we're all unfamiliar with and don't understand. Unless they explain their methods, I don't know how they're going to convince us that we can trust the results. I understand that there are...

My worry is that it's doing something self-reinforcing like that and that a sensible pattern is something that would come out regardless of what was fed into it. I don't understand the method enough to know whether my fear is reasonable.

This is Retraction Watch, though, just with more money, and IIRC, they've already been good on PACE.

People seemed to have reservations about the machine-learning approach in the Zhang paper, and I worry that we're trying to figure out whether the methodology is any good by seeing whether we can make sense of the results. I'm concerned about confirmation bias. If DecodeME confirming the results...