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They are doing another trial for people with "regular" Long Covid. This was just an early trial for MIS-C, but more are on the way for all LC.

Here is another article about the study, which include some discussion with the laboratory leader: Science Daily: • "Lyme and long COVID-19 are clearly vastly different diseases, but it's possible that they share a more general mechanism of inappropriate inflammation caused by remnants of a...

Depends how long they kept looking for it I suppose. Even if it doesn't persist for years and decades (though if something persists in a mouse for decades, it would be a very significant breakthrough in its own right). It might shed some light on medium-term post-infectious symptoms (think all...

Saw this posted from Science Translational Medicine (a reputable journal), and thought it looked exciting. I also note liver involvement - there are some reports of liver issues in some people with ME… Interested to know what people think. Abstract Persistent symptoms after an acute infection...

Hi all - sorry to have missed so much of this discussion - it appears very useful. At the heart of this is one issue: for many diseases, the majority of UK disease research funding comes through the charity sector: charities make the case for donations, raise money, and spend it on research...

Both Simon and I responded quickly to say that we are happy for these reports to be shared, and that we had no wish to withold these - have they been published now?

Moved post ----- Key points from Forward ME meeting (on 22 May 2024): · DHSC presentation of responses to IDP consultation given. Reassuringly reflects ME community views well. Election affects future actions & timelines. · FME to write to all NHS Trusts/ICB heads to highlight...

Another study relevant to LongCovid which used mice. While the details are over my head, it is published in Nature - generally a strong indicator of quality: https://www.nature.com/articles/s41586-024-07873-4

One of the authors we are talking about is Akiko Iwasaki, Sterling Professor of Immunobiology and Molecular, Cellular and Developmental Biology, elected to the US National Academy of Sciences, and is currently elected president of the American Association of Immunologists. She has had 2 papers...

There is a very clear, highly restrictive policy in two cases against use of animals in testing. Even if reagents conflict with that policy (which calls into question their capability as research leaders), it is still highly restrictive in a field which does not need any additional hurdles. So...

You said "clearly ME Research UK and Action for ME does fund research that involves the use of animals". That directly contradicts their policy. If you are saying that their policies are not as they say they are, then that is a curious state of affairs. This overview puts the number of lab...

What I care about is maximising our opportunities to understand this awful disease, and avoiding barriers to progress. If that involves studies on mice undertaken in line with reasonable principles of good practice then yes, I accept that trade-off. I have real trouble with the moral...

I find this very strange. Either you think that the words and phrases used on their websites don’t mean what they say… or that the charities who say they don’t undertake studies involving animals don’t understand what they are doing. Both are pretty poor situations in my book. Regarding using...

ME Research UK From: https://www.meresearch.org.uk/research/research-grants/ "ME Research UK does not fund research which involves the use of animals." Action for ME From: https://www.actionforme.org.uk/uploads/pdfs/research-funding-assessment-process.pdf "our current policy is not to fund...

You're selectively quoting there. I went on to say: "you can't delberately infect a load of people, euthanise them, then pick them apart to understand what has happened in a subset." To my knowledge, no study has infected a load of people, euthanised them, and then picked them apart to look at...

OK, but surely the point of these studies is not to give definitive answers... Their objective in these studies is to generate hypotheses. These are ideas which can go on to be investigated further in increasingly appropriate (but perhaps less accessible) systems such as cadavres, organ bank...

I have had a look at the links - In the first you quote one person's opinion article - it's not a study of mouse studies, it's opinion. In the second your argument is that the systems are different and complex, therefore insights are meaningless. This disregards the ability to look at...

This study was not testing a finding in humans - it was looking to gain insights into how covid infection might induce cognitive impairment. It was a study to generate hypotheses. "Here we show that intranasal infection of C57BL/6J mice with SARS-CoV-2 Beta variant leads to central nervous...

And another LongCovid study benefitting from mouse models, this time in nature immunology: https://www.nature.com/articles/s41590-024-01868-z It conflicts somewhat with the idea that there are no useful mouse models for post-infectious diseases.

The study showed a difference between samples transferred from Healthy Controls and people with a specific set of LongCovid symptoms. The study showed reactivity of antibodies from ppl with LongCovid, but not healthy controls, to mouse nervous tissue. This supports a role of the immune system...