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I can't see how just the probability of choosing a hard task is a measure of effort preference. For example, what's the point of choosing a hard task with a value of $1.78 and a probability of 0.12? If you are choosing lots of those low-value high-effort tasks, then your effort preference must...

oh, thank goodness for that. posting just to bring this to the attention of more people

Watching the Biden State of the Union speech - he's just promised 12 billion for women's health research if he gets another term.

Yes, of course they should acknowledge the substantial overlap in this 'effort preference' measure between the two groups - because that's what the data showed. My question was more about what the investigators then take from that fact. If lots of ME/CFS people, not just a couple of outliers...

I agree with others responses to that reply from the NIH. The letter writer clearly knows nothing about how weak that supposed result actually is. :thumbup: I would like to know if the investigators agree that the performance of around half of the ME/CFS cohort actually did not look much...

Some posts that were heading off-topic have been moved to the main thread Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

really well said

A lot of the time, I can't believe that we actually have to take this nonsense of a study seriously. Yes, we need to know what the participants were told, and when it was decided that game play like HVF's was not acceptable. I still think, reading between the lines of the information we have...

I thought it might be useful at this point to remind ourselves what is said about the EFFrT experiment in the paper: One point I'd make from this is that Fig 3e shows the relationship between time to failure in a grip test and proportion of hard task choices. This could be an alternative...

Re the very recently set up Prudence Trust that has been funding Crawley and has Wessely on the advisory panel handing out the grants: It seems to give out small sums to lovely sounding mental health charities and then each year it gives out great whacks of money e.g. 600,000 pounds each, to...

From the Prudence Trust website:

Looking at bobbler's very lovely chart Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al the ME/CFS participants divide up into two groups. In one group they have zero to just a few failures early on in completing the hard task, and then they reliably complete the...

I'd argue that if you tried a hard task early on and it was hard to complete, you would work getting a number of easy task rewards in the bag. When you had enough of those to cover the possibility that the probability might not give you a reward, then you would think about trying the hard tasks...

But, they weren't choosing hard tasks less often. If you look at your excellent chart - Number of hard tasks, Second-half Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al both groups were choosing roughly the same number of hard tasks. What was different was...

Pre-test calibration I mentioned that back a bit - the review paper I was talking about noted that there were a number of studies that did this calibration. I'll paste the link to the study here - it's one of the ones that bobbler noted. : Examining the reliability and validity of two versions...

One of the comments: Doctors so often don't seem to get that being 'reassured' that everything's fine when you can't do a quarter of what you used to do and feel bloody awful isn't actually that helpful. Reassurance featured heavily in clinical guidance for managing Chronic Fatigue I was...

great news, congratulations @DMissa. Nice to see the Mason Foundation selecting what promise to be good studies. Is there any detail in the public domain? Daniel, can you tell us what patient engagement is planned?

That's very powerful testimony - and of course this is coming from someone who was a child when under Crawley's care

From the CFS personal story on his website - it's an interesting read. He suggests there that recovery doesn't happen very often. Cortisol - I must write a paper on cortisol in ME/CFS one day: